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Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
Abstract Book
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Purmojärven Isopelliset II
Purmojärven Isopelliset II sisältää Isopellisen kylän uudisasukkaan Lauri Bjöninpoika Pellisen sukutauluja. Kirjassa on 12 sukupolvea Laurin jälkeläisiä 1500-luvun lopulta lähtien.
Molecular Mechanisms of Notch Signaling
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
Museums of the World
Museums of the World covers in its 13th edition 52,953 museums in 201 countries, listed hierarchically by country and place, and within places, alphabetically by name. A separate chapter records 504 museum organizations in 131 countries with addresses. The museums are coded by 22 categories identifying the focus and type of each institution. A typical entry contains the following details: name of the museum in the original language with English translation where necessary, address, telephone number, fax, eMail address and URL, museum type, year of foundation, name of the director and museum staff, special collections and equipment, number of the entry. In addition, there is an alphabetical index of museums, a subject index, an index of persons covering academic staff working in museums, and a personality index, recording artists whose works are shown predominantly in a specific museum and/or refering to memorabilia of famous individuals.
Subjectivity, Citizenship and Belonging in Law
This collection of articles critically examines legal subjectivity and ideas of citizenship inherent in legal thought. The chapters offer a novel perspective on current debates in this area by exploring the connections between public and political issues as they intersect with more intimate sets of relations and private identities. Covering issues as diverse as autonomy, vulnerability and care, family and work, immigration control, the institution of speech, and the electorate and the right to vote, they provide a broader canvas upon which to comprehend more complex notions of citizenship, personhood, identity and belonging in law, in their various ramifications.
