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Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
Abstract Book
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Purmojärven Isopelliset II
Purmojärven Isopelliset II sisältää Isopellisen kylän uudisasukkaan Lauri Bjöninpoika Pellisen sukutauluja. Kirjassa on 12 sukupolvea Laurin jälkeläisiä 1500-luvun lopulta lähtien.
Inflammation in Parkinson's Disease
Parkinson’s Disease (PD) is a progressive neurodegenerative disease with a prevalence of 0.1% of the global population, and 5-10% patients are under 40 years of age. Several text books have been published on various aspects of PD to date, including research and clinical aspects. However these do not emphasize the inflammatory pathways and pathways of neurodegeneration in PD. Inflammation in Parkinson’s Disease brings advances in research together with current literature and evidence. This concise volume covers the fundamentals of neuroimmunology and inflammatory models, the interactions between pathways of neurodegeneration and follows the concept of research work undertaken from basic science to clinical trials. Researchers, clinicians, and students interested in Parkinson's Disease are provided with a comprehensive view of translational research methods and an insight needed for developing future therapies aimed at disease modulation.
Museums of the World
Museums of the World covers in its 13th edition 52,953 museums in 201 countries, listed hierarchically by country and place, and within places, alphabetically by name. A separate chapter records 504 museum organizations in 131 countries with addresses. The museums are coded by 22 categories identifying the focus and type of each institution. A typical entry contains the following details: name of the museum in the original language with English translation where necessary, address, telephone number, fax, eMail address and URL, museum type, year of foundation, name of the director and museum staff, special collections and equipment, number of the entry. In addition, there is an alphabetical index of museums, a subject index, an index of persons covering academic staff working in museums, and a personality index, recording artists whose works are shown predominantly in a specific museum and/or refering to memorabilia of famous individuals.
