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Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
Abstract Book
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Molecular Mechanisms of Notch Signaling
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
Purmojärven Isopelliset II
Purmojärven Isopelliset II sisältää Isopellisen kylän uudisasukkaan Lauri Bjöninpoika Pellisen sukutauluja. Kirjassa on 12 sukupolvea Laurin jälkeläisiä 1500-luvun lopulta lähtien.
Museums of the World
Museums of the World covers in its 13th edition 52,953 museums in 201 countries, listed hierarchically by country and place, and within places, alphabetically by name. A separate chapter records 504 museum organizations in 131 countries with addresses. The museums are coded by 22 categories identifying the focus and type of each institution. A typical entry contains the following details: name of the museum in the original language with English translation where necessary, address, telephone number, fax, eMail address and URL, museum type, year of foundation, name of the director and museum staff, special collections and equipment, number of the entry. In addition, there is an alphabetical index of museums, a subject index, an index of persons covering academic staff working in museums, and a personality index, recording artists whose works are shown predominantly in a specific museum and/or refering to memorabilia of famous individuals.
Brain and Spinal Cord Atrophy in Multiple Sclerosis
Intended for general neurologists as well as specialists in multiple sclerosis (MS) and imaging, this book provides comprehensive discussion of central nervous system (CNS) atrophy involving the brain and spinal cord, and both the chapter authors and topics have been selected to provide state-of-the-art reviews. Key issues covered in the book include pathogenesis and its mechanisms, technical aspects of MRI measurement, the relationship between CNS atrophy and other MRI metrics, clinical relevance, the association with neurobehavioral and genetic-immunologic components of MS, and the effects of disease-modifying therapies on tissue atrophy. Pros and cons of different technical approaches are discussed critically. Special attention is devoted to CNS atrophy as a clinically relevant biologic marker of the MS disease process.
