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Brain Insulin Resistance in Neurodevelopmental and Neurodegenerative Disorders: Mind the Gap!
The failure of insulin signaling – a condition known as insulin resistance – is a key pathological feature of both type 2 diabetes (T2DM, systemic insulin resistance) and Alzheimer’s disease and related dementias (ADRDs, brain insulin resistance) and greatly contribute to their development. Considerable overlap has been identified in the risk factors, comorbidities and putative pathophysiological mechanisms of ADRDs and T2DM, thus proposing AD as type 3 diabetes.
Abstract Book
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Alzheimer's Disease Drug Development
Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.
Purmojärven Isopelliset II
Purmojärven Isopelliset II sisältää Isopellisen kylän uudisasukkaan Lauri Bjöninpoika Pellisen sukutauluja. Kirjassa on 12 sukupolvea Laurin jälkeläisiä 1500-luvun lopulta lähtien.
Autophagy
Starting in the early 1970s, a type of programmed cell death called apoptosis began to receive attention. Over the next three decades, research in this area continued at an accelerated rate. In the early 1990s, a second type of programmed cell death, autophagy, came into focus. Autophagy has been studied in mammalian cells for many years. The recen
Museums of the World
Museums of the World covers in its 13th edition 52,953 museums in 201 countries, listed hierarchically by country and place, and within places, alphabetically by name. A separate chapter records 504 museum organizations in 131 countries with addresses. The museums are coded by 22 categories identifying the focus and type of each institution. A typical entry contains the following details: name of the museum in the original language with English translation where necessary, address, telephone number, fax, eMail address and URL, museum type, year of foundation, name of the director and museum staff, special collections and equipment, number of the entry. In addition, there is an alphabetical index of museums, a subject index, an index of persons covering academic staff working in museums, and a personality index, recording artists whose works are shown predominantly in a specific museum and/or refering to memorabilia of famous individuals.
