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This book provides an overview on the organization and function of the microtubule cytoskeleton, which is essential to many cellular processes and profoundly linked to a range of human diseases. Covering basic concepts as well as molecular details, the book discusses how microtubules are nucleated and organized into ordered arrays, at different cell cycle stages and in distinct cell types. In addition, the book highlights how defects in the microtubule cytoskeleton are linked to diseases such as neurodevelopmental disorders. The book is intended for students, graduates and more senior researchers in cell and developmental biology as well as for medical doctors.
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Winner of the ASCAP Deems Taylor Award and Society of Music Theory's Wallace Berry Award This bold challenge to conventional notions about medieval music disputes the assumption of pure literacy and replaces it with a more complex picture of a world in which literacy and orality interacted. Asking such fundamental questions as how singers managed to memorize such an enormous amount of music and how music composed in the mind rather than in writing affected musical style, Anna Maria Busse Berger explores the impact of the art of memory on the composition and transmission of medieval music. Her fresh, innovative study shows that although writing allowed composers to work out pieces in the mind...
This book brings together current information on the families that make up the kinesin superfamily of molecular motors in one comprehensive text; an ideal reference for researchers looking to make comparisons between different families, for specific information on an individual family, or simply for an overview of the kinesin superfamily. Information is clearly structured and grouped according to individual families and organised in a standardised way, allowing the reader to easily search and retrieve information on this large superfamily of molecular motors and understand how its individual members carry out a diverse variety of cellular functions. Features : The first book dedicated to the...
For every summer from 1916 to 1948, Camp Meenahga, on the picturesque shoreline of Lake Michigan in Door County’s Peninsula State Park, hosted young girls and women from across the United States and Canada. From July to September each year, campers slept in canvas tents, told stories beside a massive stone fireplace, swam, canoed, sailed, hiked, rode horses, and watched the sunset from the Lookout, a gazebo with a spectacular view of the waters of Green Bay. With big ideas, little money, and no experience, Alice Orr Clark and Frances Louise “Kidy” Mabley founded Meenahga as a place for young women to refine their manners, enjoy outdoor leisure activities, and learn woodcraft. From the Lookout is an account of these experiences, a history of Camp Meenahga informed by what campers, counselors, and others left behind, including letters home, notes from Clark and Mabley, and many pages from the camp yearbook and newsletter Pack and Paddle. Brimming with nostalgia, From the Lookout brings to life the sights, sounds, and smells of an idyllic summer retreat, one that long after it closed lived on as a place of respite in the memories of those who knew and loved it best.
Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer edges of the cell and back. In Microtubule Dynamics: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate microtubule dynamics in vitro and in cells. Beginning with the question of how to analyze microtubule dynamics, the volume continues with detailed descriptions of how to isolate tubulin from different sources and with different posttranslational modifications, methods used to study microtubule dynamics and microtu...