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Antidepressants: Past, Present and Future
A comprehensive review of the current status of antidepressants - how we arrived at this point in their evolution and where we are going in both the near and the long term. It employs both a scientific and historical approach to accomplish these goals. This volume is intended for practitioners who use antidepressants on a daily basis in their practice as well as for the student and researcher. Each will find that it provides a comprehensive and logical approach to this important group of medications. This book is being published as we mark the end of the first 50 years of the modern antidepressant era.
The Search for Antidepressants - An Integrative View of Drug Discovery
Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. Currently approved antidepressants primarily enhance, or otherwise modulate monoaminergic neurotransmission, without curing the disease. Evidence indicates that only one third of patients with MDD achieve remission after treatment with a first-line antidepressant agent. Research in the past two decades has provided valuable insights into the pathophysiological understanding of MDD. However, there is an acknowledged ‘translational gap’ in the field, and few genuinely novel antidepressants have been...
Antidepressants
This accessible volume offers a holistic exploration of this diverse class of drugs, from medical, historical, cultural, and economic perspectives. Depression is one of the most commonly reported mental disorders, and it affects millions of Americans. A wide variety of medications are used to treat depression, many of which have become household names—Zoloft, Prozac, and Paxil among them. Because these medications have the ability to alter how people think and feel, however, physicians must weigh a number of factors when prescribing them, especially to teens. Antidepressants: History, Science, and Issues, a part of Greenwood's Story of a Drug series, offers a robust exploration of antidepr...
Antidepressants
Important clinical issues as the outcome of long term treatment with antidepressants, the time of onset of the antidepressant response and the limitations of the antidepressants currently available are covered in this monograph. Leading researchers in the area of clinical and experimental psychopharmacology critically assess the progress in their specialist fields. The mechanisms of action of antidepressants are considered, followed by clinical research into the role of the hypothalamic-pituitary-adrenal axis and the immune system in the biology of depression and in response to treatment. The final chapter deals with the important chemical entities now undergoing development as antidepressants. The purpose of this monograph is not only to inform but also to stimulate research into the biology of depression and the mechanisms behind the action of effective antidepressants. This monograph is of interest to psychiatrists, psychologists, pharmacologists, neuroscientists and endocrinologists.
The Antidepressant Antidote
Do you want to get off antidepressants and move toward a more full and balanced life? Have you tried several times to get off antidepressants, only to end up right back on them? If so, this book is for you. In The Antidepressant Antidote: Five Steps to Get Off Antidepressants Safely and Effectively, Bethany Butzer, Ph.D. provides practical and proven techniques to help you get off antidepressants once and for all. This life-enhancing 5-step program will teach you: How to get the support you need as you taper off antidepressants. Tips to deal with the withdrawal effects that can arise when reducing your antidepressant dose. Techniques to let go of stress, anxiety, sadness, and depression. Sma...
Antidepressants
Antidepressants are prescription medications that relieve the symptoms of depression. The use and abuse of antidepressants has grown steadily since their introduction. Includes statistical information and personal examples.
Antidepressant Medication Strategies
Do today's antidepressants really deliver what the pharmaceutical companies tout and what users expect?
Next Generation Antidepressants
The future of mood-disorder research: covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities.
Antidepressants and Receptor Function
Ciba Foundation Symposium 123 Antidepressants and Receptor Function Chairman: Dennis Murphy, 1986 Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses...
