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Adipose Tissue: Which Role in Aging and Longevity?
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Life-Span Extension
In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and...
The Encyclopedia of Aging
A COMPREHENSIVE RESOURCE ON GERONTOLOGY AND GERIATRICS Since its inception in 1987, The Encyclopedia of Aging has proven to be the definitive resource for scholars and students across the burgeoning and increasingly interdisciplinary fields of gerontology and geriatrics. Like its three esteemed predecessors, the fourth edition contains concise, readable explorations of hundreds of terms, concepts, and issues related to the lives of older adults, as well as timely coverage of the many new programs and services for the elderly. Updated, under the distinguished stewardship of editor-in-chief Richard Schulz to reflect the infusion of new information across the scientific disciplines, this new ed...
Cellular Ageing and Replicative Senescence
This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; ...
The Encyclopedia of Aging
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Novel Insights into the Comorbidities and Mortality in Patients with Diabetes
Diabetes is a metabolic disorder of chronic hyperglycemia that causes numerous complications. The International Diabetes Federation and World Health Organization report that approximately 537 million people worldwide have diabetes in 2021, which may increase to 700 million by 2045. Diabetes and its complications significantly lower the quality of life of patients and cause more than 4 million deaths yearly. Diabetes and its complications also increase premature mortality, increasing society's economic burden. Numerous studies reveal that the chronic multisystem injury and dysfunction can be caused by diabetes, including cardiac and cerebral vascular lesions, nephropathy, retinopathy and neur...
Autophagy in Endocrine-metabolic Diseases Associated with Aging
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Ovarian Aging: Pathophysiology and Recent Development of Maintaining Ovarian Reserve, volume III
Age-related fertility decline is a striking phenomenon for women and there is an increasing tendency for later marriage and the postponement of childbearing in industrial countries. Many epidemiological observations also point out that almost one-tenth of reproductive-aged women require infertility treatment in these countries. Although the uterus is somewhat affected by ageing, the ageing ovary is considered a major but inevitable phenomenon. Consequently, preserving future fecundity is generally understood as preserving ovarian function; this is becoming a major concern for physicians specialized in reproductive medicine. Several chemicals have proved to improve or maintain the ovarian follicular pool, though the efficacy is still limited.
(Osteo)Sarcopenia & Sarcopenic Obesity, volume II
Sarcopenia is a geriatric syndrome with progressive loss of mass, quality and function of skeletal muscles associated with aging. Its prevalence may reach 30% for people over 60 in European populations. Sarcopenia is a multifactorial process: some factors lead to the development of sarcopenia and its associated negative effect on physical function. The loss of skeletal muscle fibers secondary to the reduced number of motor neurons appears to contribute significantly to the disorder, which may further include reduced levels of hormones (particularly GH, IGF-1, MGF, and testosterone), lack of protein and calories of the diet, oxidative stress, inflammatory processes etc. Sarcopenia requires a rehabilitation program to improve physical performance but also nutritional interventions: protein supplementation combined with exercise, leucine-enriched amino acids and vitamin D supplementation, as adjunctive therapy.
