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"Anecdotes, tidbits and documents to provide insight into the lives of members of the Peterson, Freeland, gardner, Snider, Hurt and many other families of Tennessee, Kentucky, Virginia and North Carolina in the 18th, 19th and 20th centuries. Also, data on the Arnold family of Texas, the Ochs family of Tennessee and New York, the Wilder family of Vermont, the Barr family of Pennsylvania, and many others."--Back cover.
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CD4+FoxP3+ regulatory T cells (Tregs) play an indispensable role in the maintenance of immune homeostasis and prevention of autoimmune diseases, and represent a major cellular mechanism of tumor immune evasion. Targeting of Tregs has great potential in the treatment of some major human diseases, including autoimmunity, transplant rejection, GvHD, and cancer, and are critical controllers of immunity to infectious pathogens. It is expected they will also be central to the control of allergic and inflammatory diseases. Understanding the biological pathways crucial for the regulation of Treg activity is a prerequisite for harnessing the immense therapeutic potential of Tregs. TNF is generally be...