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This book covers the latest techniques that enable us to study the genome in detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism
Written primarily for students embarking on an undergraduate bioscience degree, this primer introduces students to the essential topics in protein science clearly and concisely by describing the basic chemical structure of proteins, the factors that stabilize protein structures, proteinfunction, and protein evolution.It begins by placing proteins in their general context in life. They are synthesized as amino-acid sequences encoded in genomes, and fold spontaneously to three-dimensional structures. This is the point where life makes the tremendous leap from the one-dimensional world of genome and amino-acidsequences, to the three-dimensional world of protein structures - indeed, the world wh...
A vast amount of biological information about a wide range of species has become available in recent years as technological advances have significantly reduced the time it takes to sequence a genome or determine a novel protein structure. This text describes how bioinformatics can be used as a powerful set of tools for retrieving and analysing this biological data, and how bioinformatics can be applied to a wide range of disciplines such as molecular biology, medicine, biotechnology, forensic science, and anthropology.
Lesk provides an accessible and thorough introduction to a subject which is becoming a fundamental part of biological science today. The text generates an understanding of the biological background of bioinformatics.
Starting by describing the structure of proteins and explaining how these structures can be studied, this book goes on to illustrate the wide range of protein functions by showing how the shape of a protein is intimately linked to its function.
Modern computer graphics transforms protein structures into visually exciting images. 'Protein Architecture: A Practical Approach' shows the reader how to visualize protein structures, and how to design an illustration to help understand and appreciate the variety of protein folding patterns.
Lesk provides an accessible and thorough introduction to a subject which is becoming a fundamental part of biological science today. The text generates an understanding of the biological background of bioinformatics.
Proteins are essential to life, having a vital role in all living organisms. They are the ultimate micro machines: some are building blocks, joining with other substances to make the cells from which we are all formed. Some are catalysts, speeding up essential biochemical reactions to keep our cells alive. Yet others help cells to communicate, to move, and to build up the complex mix of tissues that make up our bodies. Introduction to Protein Science provides a broad ranging introduction to the contemporary study of proteins suitable for students on biosciences degrees internationally. Starting by describing the structure of proteins and how these structures can be studied, the book goes on to illustrate the wide range of functions that proteins have, showing how the shape of a protein is intimately linked to the function that it has. The book then describes how new experimental and computational techniques are helping us to predict a protein s structure and function, and how this is paving the way for us to design new proteins with specific characteristics, with exciting implications in areas such as drug design. Written by Arthur Lesk, the author of the highly successful Introduc
This book is based on a one-semester course for advanced undergraduates specializing in physical chemistry. I am aware that the mathematical training of most science majors is more heavily weighted towards analysis – typ- ally calculus and differential equations – than towards algebra. But it remains my conviction that the basic ideas and applications of group theory are not only vital, but not dif?cult to learn, even though a formal mathematical setting with emphasis on rigor and completeness is not the place where most chemists would feel most comfortable in learning them. The presentation here is short, and limited to those aspects of symmetry and group theory that are directly useful in interpreting molecular structure and spectroscopy. Nevertheless I hope that the reader will begin to sense some of the beauty of the subject. Symmetry is at the heart of our understanding of the physical laws of nature. If a reader is happy with what appears in this book, I must count this a success. But if the book motivates a reader to move deeper into the subject, I shall be grati?ed.