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Clusterin, Part B
The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s. Approaches such as cloning, expression and functional characterization of the different protein products generated by the CLU gene have now produced a critical mass of information of tremendous biological importance that are teaching us an important lesson in molecular biology of gene expression regulation. This volume brings together the contributions of top researchers in the field, providing an overview and synthesis of the latest thought and findings relating to CLU.
Sentimental Opera
Sentimental Opera is a study of the relationship between opera and two major phenomena of eighteenth-century European culture - the cult of sensibility and the emergence of bourgeois drama. A thorough examination of social and cultural contexts helps to explain the success of operas such as Paisiello's Nina as well as the extreme emotional reactions of their audiences. Like their counterparts in drama, literature and painting, these works brought to the fore serious contemporary problems including the widespread execution of deserters, the treatment of the insane, and anxieties relative to social and familial roles. They also developed a specifically operatic version of the dominant language of sensibility. This wide-ranging study involves such major cultural figures as Goldoni, Diderot and Mozart, while refining our understanding of the theatrical genre system of their time.
Tierra del fuego
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Neuroblastoma
Introduction of new technologies and their applications to neuroblastoma diagnosis, treatment, and therapy assessment are explained. Role of molecular ghenetics in diagnosis and therapy for neuroblastoma patients is detailed. Molecular detection of minimal residual neuroblastoma is described. Magnetic resonance imaging and spectroscopy are detailed for diagnosing this solid, extracranial cancer. Targets for therapeutic intervention in neuroblastoma are identified, including targeting multidrug resistance in this cancer. Ornithine decarboxylase and polyamines are novel targets for therapeutic intervention. The effectiveness of chemotherapy with oral irinotecan and temozolomide is explained. The role of transcription factors (GATA) in neuroblastoma pregression is also included.
