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This book constitutes the refereed proceedings of the Third International Workshop on Algorithms and Computation, WALCOM 2009, held in Kolkata, India, in February 2009. The 30 revised full papers presented together with 4 invited papers were carefully reviewed and selected from 102 submissions. The papers feature original research in the areas of design and analysis of algorithms, computational geometry, graph drawing and graph algorithms. The papers are organized in topical sections on computational geometry, graph algorithms, complexity, graph drawing, approximation algorithms, and randomized algorithms.
The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.
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This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neuro...
Algorithms are essential building blocks of computer applications. However, advancements in computer hardware, which render traditional computer models more and more unrealistic, and an ever increasing demand for efficient solution to actual real world problems have led to a rising gap between classical algorithm theory and algorithmics in practice. The emerging discipline of Algorithm Engineering aims at bridging this gap. Driven by concrete applications, Algorithm Engineering complements theory by the benefits of experimentation and puts equal emphasis on all aspects arising during a cyclic solution process ranging from realistic modeling, design, analysis, robust and efficient implementat...
This continuing authoritative series deals with the chemistry, materials science, physics and technology of the rare earth elements in an integrated manner. Each chapter is a comprehensive, up-to-date, critical review of a particular segment of the field. The work offers the researcher and graduate student a complete and thorough coverage of this fascinating field. - Authoritative - Comprehensive - Up-to-date - Critical