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Quality Control of Cellular Protein in Neurodegenerative Disorders
Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.
The Alzheimer's Disease Challenge, Volume II
Given the success of Volume I of this Research Topic, we are pleased to announce the launch of Volume II: “The Alzheimer's Disease Challenge”. The repeated failure of clinical trials on the amyloid-based medications and the pessimistic calculations of Alzheimer's disease cost burden for the next few decades present a severe challenge to humankind with severe social implications. In recent years, several alternative diagnostic and treatment procedures have been presented to treat and manage Alzheimer’s disease as it has been nearly impossible to suggest a holistic solution. Several revelations in human biology have highlighted the multiparametric character of the disease. Besides the amyloid aggregation and neurofibrillary tangles that result in Aβ toxicity and tau phosphorylation, processes such as Gene Mutations, Proteins Misfolding, Brain Biochemical and Histopathological Changes, Behavioral Changes, Nutrition and Metabolism Alterations, and Autonomic Dysfunctions due to Central Nervous System dysregulations are common signs and probably early diagnostic biomarkers in most of the Alzheimer's classification categories.
Acute Leukemias
Written by expert research teams, this book describes different aspects of both acute myeloid and acute lymphocytic leukemia, specifically their pathobiology, classification/diagnosis, and treatment. Chapters highlight current research as well as the gold standards for diagnosis and treatment of these diseases, examining recent advances in personalized approaches to acute leukemia.
The Neurodegeneration Revolution
The Neurodegeneration Revolution: Emerging Therapies and Sustainable Solutions provides insights into the mechanics, characteristics, behavior, application, and manufacturing of advanced materials such as nanowires, 2D materials, biomaterials, smart materials, and more. The first section discusses the mechanics and electronic and magnetic properties of nanomaterials, photonic, and photonic materials and devices, 2D magnetic materials, smart materials and coatings, metamaterials, and microdevices and sensors. The second section of the book covers manufacturing technologies and methods of previously discussed materials, outlining manufacturing techniques for additive manufacturing of metallic ...
GeNeDis 2014
The 1st World Congress on Geriatrics and Neurodegenerative Disease Research (GeNeDis 2014), will focus on recent advances in geriatrics and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments and will provide an international forum for the latest scientific discoveries, medical practices and care initiatives. Advances information technologies will be discussed along with their implications for various research, implementation and policy concerns. In addition, the conference will address European and global issues in the funding of long-term care and medico-social policies regarding elderly people. GeNeDis 2014 takes place in Corfu, Greece, 10-13 April 2014. This volume focuses on the sessions that address neurodegenerative diseases.
Interdisciplinary Approaches to Altering Neurodevelopmental Disorders
Disorder-assistive and neurotechnological devices are experiencing a boom in the global market. Mounting evidence suggests that approaches based on several different domains should move towards the goal of early diagnosis of individuals affected by neurodevelopmental disorders. Using an interdisciplinary and collaborative approach in diagnosis and support can resolve many hurdles such as lack of awareness, transport, and financial burdens by being made available to individuals at the onset of symptoms. Interdisciplinary Approaches to Altering Neurodevelopmental Disorders is a pivotal reference source that explores neurodevelopmental disorders and a diverse array of diagnostic tools and therapies assisted by neurotechnological devices. While covering a wide range of topics including individual-centered design, artificial intelligence, and multifaceted therapies, this book is ideally designed for neuroscientists, medical practitioners, clinical psychologists, special educators, counselors, therapists, researchers, academicians, and students.
Essential Guide to Neurodegenerative Disorders
Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches. - Reviews big data and neurodegeneration disorders, including gene mapping - Examines the structural basis of protein assembly into amyloid filaments in neurodegenerative disease - Covers the progress and challenges of pharmacotherapy of neurodegenerative disorders
