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Randomized Controlled Trials
Randomized controlled trials are one of the most powerful and revolutionary tools of research. This book is a convenient and accessible description of the underlying principles and practice of randomized controlled trials and their role in clinical decision-making. Structured in a jargon-free question-and-answer format, each chapter provides concise and understandable information on a different aspect of randomized controlled trials, from the basics of trial design and terminology to the interpretation of results and their use in driving evidence-based medicine. The authors end each chapter with their musings, going beyond the evidence or citations, and sometimes even beyond orthodox correct...
The Road to Medical Statistics
There has been a growing recognition of the importance of mathematical and statistical methods in the history of medicine, particularly in those areas where statistical methods are a sine qua non such as epidemiology and randomised clinical trials. Despite this expanding scholarly interest, the development of the mathematical and statistical technologies in the biological sciences has not been examined systematically. This collection of essays aims to provide a broader overview of this field, and to explore the use of these with the use of these quantitative technologies in medical and clinical cultures from the seventeenth to the twentieth centuries.
Smoking Kills
At the end of the Second World War, Britain had the highest incidence of lung cancer in the world. For the first time lung cancer deaths exceeded those from tuberculosis - and no one knew why. On 30 September 1950, a young physician named Richard Doll concluded in a research paper that smoking cigarettes was 'a cause and an important cause' of the rapidly increasing epidemic of lung cancer. His historic and contentious finding marked the beginning of a life-long crusade against premature death and the forces of 'Big Tobacco'. Born in 1912, Doll, a natural patrician, jettisoned his Establishment background and joined the Communist Party as a reaction to the 'anarchy and waste' of capitalism i...
Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Statisticians of the Centuries
Written by leading statisticians and probabilists, this volume consists of 104 biographical articles on eminent contributors to statistical and probabilistic ideas born prior to the 20th Century. Among the statisticians covered are Fermat, Pascal, Huygens, Neumann, Bernoulli, Bayes, Laplace, Legendre, Gauss, Poisson, Pareto, Markov, Bachelier, Borel, and many more.
Testing Treatments
This work provides a thought-provoking account of how medical treatments can be tested with unbiased or 'fair' trials and explains how patients can work with doctors to achieve this vital goal. It spans the gamut of therapy from mastectomy to thalidomide and explores a vast range of case studies.
