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American Colossus
Babe Ruth, Jack Dempsey, Bobby Jones, and Bill Tilden were the legendary quartet of the “Golden Age of Sports” in the 1920s. They transformed their respective athletic disciplines and captured the imagination of a nation. The indisputable force behind the emergence of professional tennis as a popular and lucrative sport, Tilden’s on-court accomplishments are nothing short of staggering. The first American?born player to win Wimbledon and a seven?time winner of the U.S. singles championship, he was the number 1 ranked player for ten straight years. A tall, flamboyant player with a striking appearance, Tilden didn’t just play; he performed with a singular style that separated him from ...
CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom
CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past d...
The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease
Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Dendritic Cells
This detailed volume provides methods that can be used to study dendritic cell (DC) ontogeny, isolation, migration, and functions. After an introduction to murine and human DC subsets and their unique transcriptional, phenotypic, and functional properties, the book continues with sections covering in vivo studies, in vitro differentiation, enrichment, functional characterization, as well as Omics approaches to study dendritic cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Dendritic Cells: Methods and Protocols is an ideal guide to familiarize readers with the current state of the art techniques to investigate these vital cells.
Molecular Mechanisms of Dendritic Cell-Mediated Immune Tolerance and Autoimmunity
Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.
