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Protein-Protein Interactions
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
Tumor Microenvironment and Cancer Therapy
It is well established that the tumor microenvironment(TME) plays a pivotal role in tumor initiation, progression and therapeutic resistance by creating a dynamic interaction with cancer cells. TME is comprised of extracellular matrix (ECM), growth factors, nutrients, blood and lymphatic vessels, and non-cancer stromal cells, which serve as a sustained niche for cancer cells to proliferate and metastasize. Notably, various cellular components in TME, including endothelial cells, fibroblasts, pericytes, adipocytes, immune cells, cancer stem cells, and vasculature, could promote tumor’s immune evasion and growth.
Advances in Intelligent Computing
The International Conference on Intelligent Computing (ICIC) was set up as an annual forum dedicated to emerging and challenging topics in the various aspects of advances in computational intelligence fields, such as artificial intelligence, machine learning, bioinformatics, and computational biology, etc. The goal of this conference was to bring together researchers from academia and industry as well as practitioners to share ideas, problems and solutions related to the multifaceted aspects of intelligent computing. This book constitutes the proceedings of the International Conference on Intelligent Computing (ICIC 2005), held in Hefei, Anhui, China, during August 23–26, 2005. ICIC 2005 r...
Snake Monarch
He was an Ink Boa Python that had cultivated for close to ten thousand years.Waiting until after his ninth Heavenly Tribulation, he would be able to enter the immortal class.He didn't expect that the heavens would actually joke with him at this moment.A woman was thrown down from the sky?This woman was actually the fisherman who he hadn't been able to find for a long time?It looked like he wouldn't be able to reach the Immortal Realm if he didn't repay this kindness!Fine! Then he would grant her a life of wealth and prosperity, a life of 100 years!What? She doesn't want it?Was it his she wanted?
My wife is A CEO
He worked diligently for several years at the job, and finally took the position of director, but was framed and insulted by the relatives of the company's CEO. In anger, he chose to resign and leave here to go to the city where his internet pal lives who are very happy to chat with.When he arrived in the new city, his relationship with this internet pal also quickly heated up. His new job was also rewarded by his hard work. Until one day, he found that the beauty who had been chatting with him for a long time on the Internet turned out to be the CEO of his company ...☆About the Author☆Yan Dou, an excellent author of online novels, is good at writing urban romance novels, and her representative works include Workplace Situation: Female Enthusiasts in Love. Her novels have attracted widespread attention for her beautiful language and fascinating storyline.
Proud Prince, I'll Take
Some people say that the person who knows you the best is not the person who sleeps next to you, but your enemy. Mo Bei, would you rather spend your life opposing me than be in my arms? Ji Mo Xun, you mistook me for someone else from the very beginning, and you've hurt me so much that I can never return ...]
Book of Wei Dynasty (Volume II)
The Twenty-Four Histories (Chinese: 二十四史) are the Chinese official historical books covering a period from 3000 BC to the Ming dynasty in the 17th century. The Han dynasty official Sima Qian established many of the conventions of the genre. Starting with the Tang dynasty, each dynasty established an official office to write the history of its predecessor using official court records. As fixed and edited in the Qing dynasty, the whole set contains 3213 volumes and about 40 million words. It is considered one of the most important sources on Chinese history and culture. The title "Twenty-Four Histories" dates from 1775 which was the 40th year in the reign of the Qianlong Emperor. This ...
Mrs. Gu, Marry Me Again
He was the high and mighty emperor of business in Peace City. She was the thorn in his side, the apple of his eye. It was a conspiracy. He had forgotten about her and everyone was laughing at her. She was full of anger! She had just returned home and accidentally bumped into his car and entered the hospital. She did everything she could, but he only said, No! No! Nonsense! Finally, he recovered his memories and she left! The truth that he had been hiding came one after another, torturing him to the point that his heart and liver ached ... Ps: She burst into laughter hit the face, torture in a smile, with tears in favor. The final text of "Married Wife Decided"
Финансовое стимулирование экономики Республики Беларусь с учетом опыта КНР
В монографии изложены результаты анализа практики финансового стимулирования китайской экономики для ускорения темпов экономического роста. Определена специфика финансового стимулирования в КНР и оценены перспективы использования этой практики в Республике Беларусь. Даны рекомендации по использованию китайских финансовых инструментов применительно к условиям белорусской экономической модели.Рассчитана на специалистов органов государственного управления, научных работников, преподавателей вузов, аспирантов, магистрантов и студентов.
