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Protein-Protein Interactions
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
ABC Dictionary of Sino-Japanese Readings
The significance of Japanese-language scholarship on China cannot be overstated. Yet much of it is largely untapped by China scholars in both the West and China, in part because they are unfamiliar with the Japanese pronunciation of Chinese characters. Even those who know Japanese are frequently frustrated when seeking an obscure reading of a personal or place name. The purpose of this volume is to enable Sinologists and others involved in Chinese studies to access entries in Japanese reference works dealing with China without going through the time-consuming process of looking up characters by radical and stroke. For users of this dictionary, it is a simple matter to find a character by loo...
AACR 2022 Proceedings: Part A Online-Only and April 10
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Tumor Microenvironment and Cancer Therapy
It is well established that the tumor microenvironment(TME) plays a pivotal role in tumor initiation, progression and therapeutic resistance by creating a dynamic interaction with cancer cells. TME is comprised of extracellular matrix (ECM), growth factors, nutrients, blood and lymphatic vessels, and non-cancer stromal cells, which serve as a sustained niche for cancer cells to proliferate and metastasize. Notably, various cellular components in TME, including endothelial cells, fibroblasts, pericytes, adipocytes, immune cells, cancer stem cells, and vasculature, could promote tumor’s immune evasion and growth.
Advances in Intelligent Computing
The International Conference on Intelligent Computing (ICIC) was set up as an annual forum dedicated to emerging and challenging topics in the various aspects of advances in computational intelligence fields, such as artificial intelligence, machine learning, bioinformatics, and computational biology, etc. The goal of this conference was to bring together researchers from academia and industry as well as practitioners to share ideas, problems and solutions related to the multifaceted aspects of intelligent computing. This book constitutes the proceedings of the International Conference on Intelligent Computing (ICIC 2005), held in Hefei, Anhui, China, during August 23–26, 2005. ICIC 2005 r...
Proud Prince, I'll Take
Some people say that the person who knows you the best is not the person who sleeps next to you, but your enemy. Mo Bei, would you rather spend your life opposing me than be in my arms? Ji Mo Xun, you mistook me for someone else from the very beginning, and you've hurt me so much that I can never return ...]
Stubborn Structures
The editor of this book has brought together contributions designed to capture the essence of post-communist politics in East-Central Europe and Eurasia. Rather than on the surface structures of nominal democracies, the nineteen essays focus on the informal, often intentionally hidden, disguised and illicit understandings and arrangements that penetrate formal institutions. These phenomena often escape even the best-trained outside observers, familiar with the concepts of established democracies. Contributors to this book share the view that understanding post-communist politics is best served by a framework that builds from the ground up, proceeding from a fundamental social context. The bo...
S-Heterocycles
Heterocyclic compounds are vital in synthetic chemistry, pharmaceuticals, agrochemicals, and materials science. The concept of S-heterocyclic compounds revolves around organic compounds that contain heterocyclic rings, and sulfur (S) is one of the heteroatoms within the ring structure. S-enabled heterocycles have emerged as one of the key classes of heterocycles and have attracted tremendous attention attributed to their identity as ‘privileged pharmacological structures’ across natural products and highly active pharmaceutical agents. This edited volume reports the latest developments in practical and selective reactions and methods and provides details of the structural diversity of he...
