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Glia
The majority of cells in the nervous system are glia. Long thought of as passive bystanders, glial cells are increasingly being appreciated for their active roles in nourishing, supporting, and protecting the neuronal cells that relay electrical signals through the nervous system. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the development of the major classes of glial cells-astrocytes, oligodendrocytes, Schwann cells, and microglia-and their roles in normal physiology and disease. The contributors describe how glia help establish and refine synaptic connections, maintain the metabolic and ionic milieu of nerve cells, m...
Delusions of Gender: How Our Minds, Society, and Neurosexism Create Difference
Sex discrimination is supposedly a distant memory. Yet popular books, magazines and even scientific articles defend inequalities by citing immutable biological differences between the male and female brain. Why are there so few women in science and engineering, so few men in the laundry room? Well, they say, it's our brains.
The History of Neuroscience in Autobiography
This book is the second volume of autobiographical essays by distinguished senior neuroscientists; it is part of the first collection of neuroscience writing that is primarily autobiographical. As neuroscience is a young discipline, the contributors to this volume are truly pioneers of scientific research on the brain and spinal cord. This collection of fascinating essays should inform and inspire students and working scientists alike. The general reader interested in science may also find the essays absorbing, as they are essentially human stories about commitment and the pursuit of knowledge. The contributors included in this volume are: Lloyd M. Beidler, Arvid Carlsson, Donald R. Griffin, Roger Guillemin, Ray Guillery, Masao Ito. Martin G. Larrabee, Jerome Lettvin, Paul D. MacLean, Brenda Milner, Karl H. Pribram, Eugene Roberts and Gunther Stent. Key Features * Second volume in a collection of neuroscience writing that is primarily autobiographical * Contributors are senior neuroscientists who are pioneers in the field
Neuroglia
Graduate students in neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology will find the book indispensable. It is also a vital companion for researchers in these fields as well as clinicians in neurology, neurosurgery, neuropathology, neuro-oncology, physiatry, and psychiatry."--BOOK JACKET.
A Lab of One's Own
A riveting memoir-manifesto from the first female director of the National Science Foundation about the entrenched sexism in science, the elaborate detours women have taken to bypass the problem, and how to fix the system. If you think sexism thrives only on Wall Street or in Hollywood, you haven’t visited a lab, a science department, a research foundation, or a biotech firm. Rita Colwell is one of the top scientists in America: the groundbreaking microbiologist who discovered how cholera survives between epidemics and the former head of the National Science Foundation. But when she first applied for a graduate fellowship in bacteriology, she was told, “We don’t waste fellowships on wo...
The Spike
The story of a neural impulse and what it reveals about how our brains work We see the last cookie in the box and think, can I take that? We reach a hand out. In the 2.1 seconds that this impulse travels through our brain, billions of neurons communicate with one another, sending blips of voltage through our sensory and motor regions. Neuroscientists call these blips “spikes.” Spikes enable us to do everything: talk, eat, run, see, plan, and decide. In The Spike, Mark Humphries takes readers on the epic journey of a spike through a single, brief reaction. In vivid language, Humphries tells the story of what happens in our brain, what we know about spikes, and what we still have left to u...
The Hidden Brain
What if it is simply unconscious biases — in the way of memory, emotion and attention — that produce most misunderstandings and conflicts between people, groups and even nations? How can you tell if it isn't just your brain running on 'auto-pilot' that makes your moral decisions for you, instead of the logical thinking you've nurtured and developed? Reminiscent of Malcolm Gladwell's Blink, The Hidden Brain takes a look at how we actually think both consciously and unconsciously. In The Hidden Brain: how our unconscious minds elect presidents, control markets, wage wars, and save our lives, author and science journalist Shankar Vedantam describes unique cases of everyday unconscious decis...
The Autobiography of a Transgender Scientist
A POIGNANT LGBT MEMOIR: A leading trans neuroscientist recounts his gender transition, his groundbreaking scientific work, and his advocacy for gender equality in STEM. “A portrait of a singular personality that was shaped by his status as an outsider.” —Science Ben Barres was known for his groundbreaking scientific work and advocacy for gender equality in science. In this autobiography, completed shortly before his death from pancreatic cancer in December 2017, Barres (born in 1954) describes a life full of remarkable accomplishments—from his childhood as a precocious math and science whiz to his experiences as a female student at MIT in the 1970s to his gender confusion and later t...
Glia in Health and Disease
The book will highlight the role played by glial cells in the central and peripheral nervous systems in both healthy and unhealthy individuals. Among all processes involved, we will discuss the importance of the enteric nervous system in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions such as metabolic syndrome. We will also look at the relevance of astrocytes during synaptic transmission and the regulation of plasticity by releasing gliotransmitters. Ultimately, we will highlight the influence of astrocytes during the development of a number of neurodegenerative diseases, such as multiple sclerosis and Alzheimer’s disease, focusing on how the serum levels of the astrocytic protein S100B can be used as a biomarker for clinical decisions.
Purifying and Culturing Neural Cells
Composed of countless neurons, glia, and vascular cells, the nervous system innervates all parts of the body to function as a vast communication network. This complexity makes it challenging to examine neural properties at the cellular and molecular levels. Cell culture systems for specific neural cell types are thus essential for studies of their development and function. This laboratory manual provides step-by-step protocols for isolating specific cell populations from rodent tissues and culturing them under conditions that closely resemble those in vivo. The contributors describe in detail how to dissect the brain, spinal cord, and other tissues; how to separate cells using mechanical and...
