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Endocrinology
Leading scientists and clinicians create a concise yet comprehensive encyclopedia of the latest scientific and clinical knowledge covering the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human disease. Their book illuminates the scientific principles underlying all aspects of hormone secretion and hormone action and leads the reader toward a full understanding of the pathogenesis of human endocrine disease. It will be indispensable to physicians and scientists as well as to students who need a high-quality, up-to-date critical survey and reference to endocrinology today.
Advances in Eicosanoid Research
Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.
Prostaglandins, Leukotrienes, and the Immune Response
This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.
Lipid Metabolism
Lipid Metabolism focuses on the regulation and metabolism of lipids. This book is composed of 10 chapters that specifically deal with fatty acids, prostaglandins, glycerides, glycerophosphates, cholesterol, isoprenoids, and aromatic compounds. This text starts with an overview of fatty acid metabolism and its controlling factors. This topic is followed by discussions on the physiochemical aspects of oxidative metabolism of fatty acids, with a special emphasis on the role of carnitine in this process. A chapter highlights the several important aspects of higher plant lipid metabolism. Other chapters are devoted to the structures, biosynthesis, and metabolism of prostaglandins, bacterial lipids, phospholipids, glycerides, and steroids. The final chapters describe the biogenesis of aromatic substances through the polyketide path, including polyisoprenoid quinines and related compounds.
Peroxidases and Catalases
SINGLE SOURCE GUIDE TO PEROXIDASES AND CATALASES Reflecting the important historical discoveries and exciting research in the field in recent years, Peroxidases and Catalases: Biochemistry, Biophysics, Biotechnology and Physiology provides a much-needed systematic, up-to-date treatment of peroxidases and catalases. From the structure and properties of the various superfamilies to current applications of peroxidases, the book consolidates vast amounts of information previously scattered in the professional literature, covering all aspects of these ubiquitous enzymes that act on a variety of substances and processes in living systems—their properties, reactions, crystal structures, cloning, ...
Phylogenetic Perspectives on the Vertebrate Immune System
This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB). The conference was held in Copper Mountain, CO from July 11-16, 1999. It was a an extension of a New York Academy of Sciences meeting entitled "Primordial Immunity: Foundations for the Vertebrate Immune System" held on May 2-5,1993 at the Marine Biological Laboratories in Woods Hole, MA. The proceedings of that meeting were published in The Annals of the New York Academy of Sciences (volume 712). At that meeting all the attendes agreed that this type of conference (a relatively small focused g...
Structure of Biological Membranes
Since 1965 the Nobel Foundation sponsors, through grants from the Bank of Sweden Tercentenary Fund, Sym posia on subjects which are considered to be of central scientific importance and for which new results of a special interest have been reached. The aim of these Symposia is to bring together, by personal invitation, a limited number of leading scientists from various countries to discuss the current research situation within the field and to define the most urgent problems to be solved. One of the most important fields in modern biome dical research concerns the structure and function of biological membranes. Research on this subject is very active and important scientific contributions a...
Central Regulation of the Endocrine System
According to the classical concept of Geoffrey Harris the pituitary gland is controlled by the brain by means of blood-borne chemical messengers produced by central neurons. The recent isolation and structural characterization of several such messengers by Roger Guillemin and Andrew Schally and their collaborators brought the final proof for this hypothesis. This also meant that the extensive knowledge collected in the field of neurobiology now became highly relevant for the endocrinologists. For this reason it was felt important to organize a symposium which brought together experts in the fields of neurobiology and endocrinology. The idea was to focus the attention on neuronal mechanisms, ...
Molecular and Biological Aspects of the Acute Allergic Reaction
Ladies and Gentlemen, dear guests, It is my great pleasure and privilege to extend our heartiest wel come to you, the participants of this 33rd Nobel symposium. To those of you who have not attended a Nobel symposium before I would like just briefly to explain why Nobel's name is linked to this series of symposia. Alfred Nobel, who died in San Remo in 1896, donated the main part of his fortune to the promotion of in ternational science and culture by establishing annual prizes for outstanding discoveries or contributions within five fields, che mistry, physics, physiology or medicine, literature and peace. The annual awards should be distributed by five corresponding prize committees out of ...
Biochemistry of Silicon and Related Problems
Silicon chemistry was initiated in 1823 by Berzelius who prepared elemental silicon. In many ways silicon was considered a typical opposite of carbon, although the two elements are closely related as to their electronic structure, both having four valence electrons. The properties of their compounds are, however, extreme ly different. Both form extended structures, but in different ways - carbon by covalent carbon-carbon bonds; silicon by polar silicon- -oxygen-silicon bonds. The complex carbon compounds are integral parts of all living matter, plants and animals. The corresponding silicon compounds build up a major part of dead matter, soils and minerals. As recently as twenty years ago the...
