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Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. - Features a wide range of toxicants and their effects on mitochondrial physiology - Covers molecular markers of mitochondrial intoxication - Includes case studies that illustrate the health impacts of toxicity upon mitochondria - Considers future directions regarding the study of mitochondrial intoxication
In this work, esteemed architectural historian Neil Levine investigates the complex history of representation from the 18th to the 20th century. Using the lens of a continuous theoretical argument, Levine provides a detailed survey and critical analysis of major works by a host of modern architects.
Tapestries were among the most prestigious of art forms, created for the mightiest in the land and valued for centuries. Despite its illustrious history, tapestry weaving is actually a simple technique that requires little equipment or expenditure, and can be done anywhere. Written by a prominent tapestry weaver, this lavishly illustrated book gently leads you through the whole process with detailed diagrams and exciting work by contemporary weavers. It will be useful to the absolute beginner, but experienced weavers will also find new ideas and techniques to tempt and inspire them. The book includes a step-by-step guide to setting up a small frame loom and starting to weave; basic and more advanced techniques, and how to create shapes and textures; advice on taking your work into the third dimension, whether bas relief or fully sculptural; information on the qualities of different materials and how they can be used to create the effects you want; and design ideas for tapestry and how to follow supplied designs. This will be an essential source book for experienced and novice weavers, and is beautifully illustrated with 190 colour illustrations and diagrams.
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