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Systems Biology
This text not only describes the current developments in systems biology, systems synthetic biology, and systems metabolic engineering for engineering and biology researchers but also discusses challenges and future prospects for systems biology and the concept of systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering.
Systems Immunology and Infection Microbiology
Systems Immunology and Infection Microbiology provides a large amount of biological system models, diagrams and flowcharts to illustrate development procedures and help users understand the results of systems immunology and infection microbiology. Chapters discuss systems immunology, systems infection microbiology, systematic inflammation and immune responses in restoration and regeneration process, systems' innate and adaptive immunity in infection process, systematic genetic and epigenetic pathogenic/defensive mechanism during bacterial infection on human cells is introduced, and the systematic genetic and epigenetic pathogenic/defensive mechanisms during viral infection on human cells. Th...
Systems Cancer Biology
Cancer is a complex and heterogeneous (systematic) disease that exhibits high levels of robustness against various therapeutic interventions. Due to the complex, heterogeneous, and evolving nature of cancer, it is essential for a system-oriented view to be adopted in order to understand the pathogenic mechanism of cancer which will eventually lead to the drug discovery and treatment of patients. This book not only provides new insights from system modeling and large scale experimental data, but also will allow the reader to perceive the systematic characteristics of cancer under some micro-environments. Based on the systems biology method and genome-wide high throughput data, the book presen...
Big Mechanisms in Systems Biology
Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification explains big mechanisms of systems biology by system identification and big data mining methods using models of biological systems. Systems biology is currently undergoing revolutionary changes in response to the integration of powerful technologies. Faced with a large volume of available literature, complicated mechanisms, small prior knowledge, few classes on the topics, and causal and mechanistic language, this is an ideal resource. This book addresses system immunity, regulation, infection, aging, evolution, and carcinogenesis, which are complicated biological systems with inconsiste...
Multi-Objective Optimization System Designs and Their Applications
This book introduces multi-objective design methods to solve multi-objective optimization problems (MOPs) of linear/nonlinear dynamic systems under intrinsic random fluctuation and external disturbance. The MOPs of multiple targets for systems are all transformed into equivalent linear matrix inequality (LMI)-constrained MOPs. Corresponding reverse-order LMI-constrained multi-objective evolution algorithms are introduced to solve LMI-constrained MOPs using MATLAB®. All proposed design methods are based on rigorous theoretical results, and their applications are focused on more practical engineering design examples. Features: Discusses multi-objective optimization from an engineer’s perspe...
Systems Synthetic Biology
Prof. Chen received the Ph.D degree from the University of Southern California in 1982. He was a professor at National Tsing Hua University and became a distinguished chair professor in 2014. He is a life fellow of IEEE. He has published about 300 journal papers in control, signal processing, communication, systems and synthetic biology. Dr. Hsu received his Ph.D degree form National Tsing Hua University in 2015. Book Description: In this book, the synthetic gene circuits are modeled by nonlinear stochastic systems to consider random genetic variations and random in vivo environmental disturbances. The authors' design purpose is to engineer a robust genetic circuit to achieve a desired behav...
Robust Engineering Designs of Partial Differential Systems and Their Applications
Most systems in science, engineering, and biology are of partial differential systems (PDSs) modeled by partial differential equations. Many books about partial differential equations have been written by mathematicians and mainly address some fundamental mathematic backgrounds and discuss some mathematic properties of partial differential equations. Only a few books on PDSs have been written by engineers; however, these books have focused mainly on the theoretical stabilization analysis of PDSs, especially mechanical systems. This book investigates both robust stabilization control design and robust filter design and reference tracking control design in mechanical, signal processing, and co...
Stochastic Game Strategies and their Applications
Game theory involves multi-person decision making and differential dynamic game theory has been widely applied to n-person decision making problems, which are stimulated by a vast number of applications. This book addresses the gap to discuss general stochastic n-person noncooperative and cooperative game theory with wide applications to control systems, signal processing systems, communication systems, managements, financial systems, and biological systems. H∞ game strategy, n-person cooperative and noncooperative game strategy are discussed for linear and nonlinear stochastic systems along with some computational algorithms developed to efficiently solve these game strategies.
Systems Evolutionary Biology
Systems Evolutionary Biology: Biological Network Evolution Theory, Stochastic Evolutionary Game Strategies, and Applications to Systems Synthetic Biology discusses the evolutionary game theory and strategies of nonlinear stochastic biological networks under random genetic variations and environmental disturbances and their application to systematic synthetic biology design. The book provides more realistic stochastic biological system models to mimic the real biological systems in evolutionary process and then introduces network evolvability, stochastic evolutionary game theory and strategy based on nonlinear stochastic networks in evolution. Readers will find remarkable, revolutionary infor...
H [infinity] Robust Designs and Their Applications to Control, Signal Processing, Communication, Systems and Synthetic Biology
H? Robust design is an advancing technology which aims to achieve the system design purpose under intrinsic random fluctuation and external disturbance. This book introduces several robust design methods, some of which include linear to nonlinear systems and frequency to time domain. This book provides not only a complete theoretical development and application of H? robust design over the last three decades, but also an integrated platform for control, signal processing, communication, systems and synthetic biology. Based on the theoretical H? robust design results, the authors also give some practical design examples to illustrate the procedure and validate the performance of the proposed H? method with computational simulations and tables.
