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Structure, Function, and Genetics of Ribosomes
During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramati cally different. We have an almost bewildering variety of information de tailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for replicating, distributing, and modifying biological information. We have learned a ...
Biomolecular Structure and Function
Biomolecular Structure and Function covers the proceedings of the 1977 ?Cellular Function and Molecular Structure: Biophysical Approaches to Biological Problems? symposium. It summarizes the application of several biophysical techniques to molecular research in biology. This book starts by describing the use of deuterium-labeled lipids, as monitors of the degree of organization of membrane lipids. It also describes the use of carbon-13-labeled lipids, as indicators of molecular mobility. It explains the lipid-protein interactions involving two integral membrane proteins, mitochondrial cytochrome oxidase and calcium-dependent ATPase of muscle sarcoplasmic reticulum. The book goes on to presen...
Progress in Nucleic Acid Research and Molecular Biology
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology Features contributions from leaders in their fields Contains abundant references
Cell Biology A Comprehensive Treatise V4
Cell Biology, A Comprehensive Treatise, Volume 4: Gene Expression: Translation and the Behavior of Proteins discusses the translation of genetic information into proteins. It also explains the activities and behaviors of proteins, which is the final stage of gene expression. This book opens with a discussion of the components and mechanism of the translational machinery – their structures, biogenesis, and cellular levels. It then explains the protein synthesis, wherein each chapter focuses on one aspect of the detailed process. Other topics covered in this book are the structure and function of cytoplasmic ribonucleoprotein complexes and the proteolytic cleavage in the posttranslational processing of proteins. This text also covers the regulation of enzyme activity and the movement of material between nucleus and cytoplasm. The last three chapters are more in-depth discussions on protein synthesis, intracellular transport, regulation, and secretion. As with the other volumes of this book series, readers will definitely benefit from the vast information provided in this book regarding protein, its activities, behaviors, and synthesis.
Chromatin
Contemporary views on the structure and function of chromatin are presented and the history of the development of these ideas as well as the nature of the nucleic acid and protein components of chromatin are reviewed. The structure of chromatin is studied at several levels, and its modes of transcription and replication are analyzed. Chromatin provides researchers with a critical evaluation of current knowledge. It combines much information that has never before been assembled, and evaluates and interrelates it in a critical way. This has not been done before so that readers are not only provided with an overview, but with extensive references to the literature (there are about 2000 references in all).
Split and Splice
"Esteemed historian and philosopher of science Hans-Jörg Rheinberger explores the incredible diversity of scientific experimentation in his new book, which extends his ground-breaking epistemological studies of the life sciences and the experimental practices that have made them so productive. Rheinberger explores the materiality of experiment, of its objects and instruments, the construction of models, and myriad ways of making things visible. The first part of the book is devoted to the circumstances and conditions that give the process of experimentation its structural cachet and make it a device from which novelty can emerge. Then, in the second part, Rheinberger focuses on the relations that experimental systems develop among each other, specifically their characteristic temporal, spatial, and narrative dimensions. The concepts that guide his investigation emerge through accessible examples, most of which are drawn from molecular biology, including from the author's own laboratory notebooks from his years researching ribosomes. This is a tour de force by one of today's most influential theorists of scientific practice"--
Membrane Protein Transport
This is the first volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.
The Avalanche Handbook, 4th Edition
More than 75,000 copies sold of previous editions New chapter on risk management Includes new photographs and updated illustrations The Avalanche Handbook needs no introduction. For this new fourth edition of the course-adopted and internationally recognized book, David McClung has completed an in-depth review and update of the entire text, as well as consulted outside experts in explosives, search and rescue, and other key topics. Comprehensive sections cover the formation, character, effects, and control of avalanches; avalanche terrain and forecasting; safety and rescue; risk management, preventive and protective measures; and more. Technical yet accessible and with extensive photos, illustrations, graphs, and charts throughout, The Avalanche Handbook will continue to be essential reading for avalanche professionals and serious winter backcountry adventurers.
Current Topics in Cellular Regulation
Current Topics in Cellular Regulation: Volume 22 is a collection of papers that deals with eukaryotic protein synthesis, lysosomal thiol proteinases, and the properties of adenylosuccinate synthetase. Other papers discuss the regulation of acetyl-CoA carboxylase, ornithine cycle, and seminal vesicle development and function. One paper investigates the poly ADP-ribosylation of protein, particularly in quantifying synthesis and in the function of the polymer. Another paper observes the construction of a reconstituted cell-free system in which there is for the first time a catalytic use, followed by a recycling of eIF-2. A eukaryotic regulatory factor or eukaryotic recycling factor (eRF) is a p...
Translational Regulation of Gene Expression 2
This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokine...
