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Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.
Prevalence of brain related diseases is expected to increase significantly in the next decades. Therefore, there is a vital need to develop effective, personalized models of human brain that can provide information about brain development, and the unique neurobiology of brain disorders. The use of biomaterials can play a strategic role for the future understanding and treatment of complex CNS diseases. Three-dimensional brain cultures have shown promise in disease modelling, cell transplantation and modulation of tissue repair.
Attachment of dissimilar materials in engineering and surgical practice is a perennial challenge. Bimaterial attachment sites are common locations for injury, repeated injury, and mechanical failure. Nature presents several highly effective solutions to the challenge of bimaterial attachment that differ from those found in engineering practice. Structural Interfaces and Attachments in Biology describes the attachment of dissimilar materials from multiple perspectives. The text will simultaneously elucidate natural bimaterial attachments and outline engineering principles underlying successful attachments to the communities of tissue engineers and surgeons. Included an in-depth analysis of the biology of attachments in the body and mechanisms by which robust attachments are formed, a review of current concepts of attaching dissimilar materials in surgical practice and a discussion of bioengineering approaches that are currently being developed.
Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material scie...
Describes the structure and mechanics of a wide range of cellular materials in botany, zoology, and medicine.
Advances in manufacturing and industrial engineering in terms of advanced and latest technologies are required nowadays to attend the accelerated demands of high quality, productivity, and sustainability simultaneously. This book fulfils the requirement by offering unique comprehensive chapters on advances in manufacturing and industrial engineering technologies with an emphasis on Industry 4.0. This book sheds light on advances in the field of manufacturing and industrial engineering for enhancement in productivity, quality, and sustainability. It comprehensively covers the recent developments, latest trends, research, and innovations being carried out. 3D printing, green manufacturing, com...
This book provides a comprehensive overview of the state-of-the-art research as well as current challenges and strategies to reconstruct large bone defects employing 3D printing technology. Various topics covered include different 3D printing technologies that can be applied for bioengineering bone, the aspects of basic bone biology critical for clinical translation, tissue engineering platforms to investigate the bone niche microenvironment, the pathway to clinical translation, and regulatory hurdles. Bone Tissue Engineering: State-of-the-Art in 3D Printing is an ideal book for students and researchers interested in learning more about the latest advances in employing different 3D printing technologies for bone tissue engineering.
Tribo-Behaviors of Biomaterials and Their Applications enables the reader to make an informed choice in the selection of biomaterials that aid the creation of safe and long-lasting surgical devices. Looking at metals, ceramics, and polymers with craniofacial, cardiovascular, spinal, dentistry, and orthopedic applications, this book is an essential guide to tribology in biomaterials. Handling wear within biodevices is a pressing issue due to the continuous friction and corrosion within the body. It is further complicated by the involvement of body fluids, which can lead to revision surgery to relieve pain. In order to lessen this, engineers can choose a biomaterial better suited to the applic...