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This textbook shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The material is intended for advanced level undergraduate courses in genetics and evolutionary biology, graduate students in evolutionary biology and human genetics, and researchers in related fields who wish to learn evolutionary genetics. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure.
Less than 450 years ago, all European scholars believed that the earth was the centre of a universe that was at most a few million miles in extent, and that the planets, sun, and stars all rotated around this centre. Less than 250 years ago, they believed that the universe was created essentially in its present state about 6000 years ago. Less than 150 years ago, the special creation by God of living species was still dominant. The relentless application of the scientific method of inference from experiment and observation, without reference to religious, or governmental authority has completely transformed our view of our origins and relation to the universe, in less than 500 years. Few wou...
This text is about the central role of evolution in shaping the nature and diversity of the living world. It describes the processes of natural selection, how adaptations arise, and how new species form, as well as summarizing the evidence for evolution
Spanning evolutionary science from its inception to its latest findings, from discoveries and data to philosophy and history, this book is the most complete, authoritative, and inviting one-volume introduction to evolutionary biology available. Clear, informative, and comprehensive in scope, Evolution opens with a series of major essays dealing with the history and philosophy of evolutionary biology, with major empirical and theoretical questions in the science, from speciation to adaptation, from paleontology to evolutionary development (evo devo), and concluding with essays on the social and political significance of evolutionary biology today. A second encyclopedic section travels the spe...
The populations of many species of animals and plants are age-structured, i.e. the individuals present at any one time were born over a range of different times, and their fertility and survival depend on age. The properties of such populations are important for interpreting experiments and observations on the genetics of populations for animal and plant breeding, and for understanding the evolution of features of life-histories such as senescence and time of reproduction. In this new edition Brian Charlesworth provides a comprehensive review of the basic mathematical theory of the demography and genetics of age-structured populations. The mathematical level of the book is such that it will be accessible to anyone with a knowledge of basic calculus and linear algebra.
The theoretical results in this monograph indicate that life provides alternative strategies to aging. The groundbreaking findings open a completely new field of research. The author gets away from the human centered vision of life showing that aging in any organism does not necessarily correspond to deterioration and senescence. The central insight of this monograph is: to deeply understand why some species age it is necessary to understand why other species do not.
In evolution, most genes survive and spread within populations because they increase the ability of their hosts (or their close relatives) to survive and reproduce. But some genes spread in spite of being harmful to the host organism—by distorting their own transmission to the next generation, or by changing how the host behaves toward relatives. As a consequence, different genes in a single organism can have diametrically opposed interests and adaptations.Covering all species from yeast to humans, Genes in Conflict is the first book to tell the story of selfish genetic elements, those continually appearing stretches of DNA that act narrowly to advance their own replication at the expense ...
Equally important, Rose surveys the entire field, offering colorful portraits of many leading scientists and shedding light on research findings from around the world. We learn that rodents given fifteen to forty percent fewer calories live about that much longer, and that volunteers in Biosphere II, who lived on reduced caloric intake for two years, all had improved vital signs. Perhaps most interesting, we discover that aging hits a plateau and stops - at least, it does so in fruit flies."--Jacket.
This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.
This book addresses several key issues in the biological study of death with the intent of capturing their genealogy, the assumptions and presuppositions they make, and the way that they open specific new research avenues. The book is divided into two sections: the first considers physiology and the second evolutionary biology. In the first part, Huneman reconstructs a conceptual genealogy of experimental physiology based on an in-depth analysis of Bichat's investigations of death processes. In the second part he explains that biologists in the late 1950s put forth a research framework that evolutionarily accounts for death in terms of either an effect of the weakness of natural selection or a by-product of natural selection for early reproduction. He illustrates how the biology of death is a central field and that studying it provides insight into the way that the epistemic structure of this knowledge has been constituted, persists until now, and may conflict with some traditional philosophical ideas.