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The selectins are the most recently discovered, and the smallest family of cell adhesion molecules. They not only mediate lymphocyte homing but their binding reaction also forms the first step in the entry of leukocytes to inflamed tissues. The inflammatory response is crucial in the host's defence against infectious micro-organisms, but can go drastically wrong, damaging host tissues in an acute reaction. Carbohydrate based selectin antagonists, as well as anti-selectin antibodies have been successfully used to combat this reaction in various animal models. Summarizing the present knowledge about the molecular mechanisms of selectin mediated cell adhesion, this volume forms an indispensable review of an important area of research. Its in-depth handling of the consequences of this research for various physiological and pathophysiological processes will also be vital to the clinician specialising in inflammatory disorders.
Backpacker brings the outdoors straight to the reader's doorstep, inspiring and enabling them to go more places and enjoy nature more often. The authority on active adventure, Backpacker is the world's first GPS-enabled magazine, and the only magazine whose editors personally test the hiking trails, camping gear, and survival tips they publish. Backpacker's Editors' Choice Awards, an industry honor recognizing design, feature and product innovation, has become the gold standard against which all other outdoor-industry awards are measured.
Frank Close, a leading physicist and talented popular science writer, reveals the true story of the cold fusion controversy--a story ignored until now in spite of the glare of publicity surrounding Martin Fleischmann and Stanley Pons. On March 23, 1989, these two Utah scientists held an astonishing press conference, maintaining that they had succeeded, working in secret, in harnessing atomic fusion. What was the basis for their claims to have achieved cold fusion in a test tube in a basement laboratory, while other scientists--using magnets as big as houses and temperatures hotter than those in the center of the sun--were failing to produce as much power as they were using? Why did Fleischma...
Fish Respiration synthesizes classical literature and highlights recent developments pertaining to the respiratory physiology of fishes. Compiled by a team of international researchers, this comprehensive and authoritative review of the respiratory physiology of fishes will appeal to any comparative physiologist interested in this subject. - First volume in the series dedicated solely to the respiratory system - Contributors are world leaders in their respective areas - Includes completely up-to-date material on the topic of fish physiology
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Devoted to fishes of high latitudes (Arctic and Antarctic). This book includes themes such as: the uniqueness of the physiology of fishes that live in cold polar environments, an analysis of physiological patterns exemplified by fishes that live poles apart, and how fishes differ from fishes living in more temperate and tropical habitats.
What should parents expect during their child's first year of college? Roger Martin, double president emeritus of two colleges, spent a year visiting five diverse colleges--public and private, large and small, elite and non-elite--in order to offer the parents of college-bound seniors a comprehensive overview of the first-year college experience. In addition to a stint with dorm life and time with students and professors, Martin draws from conversations with a wide variety of campus administrators and staff members--in financial aid, campus police, sports, health care, and disabilities accommodations. We join Martin, for example, as he and a campus safety officer walk around campus on a busy...
This book provides a comprehensive collection of timely reviews of our current understanding of the fundamental principles of nitrogen metabolism and excretion in fish. Emphasis is placed on critical assessment of how new studies impact these topics, and the articles reflect the diversity of current research approaches.