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Translational Side of Emerging Invasive and Non-Invasive Stimulation Therapies
  • Language: en
  • Pages: 188
From Sex Differences in Neuroscience to a Neuroscience of Sex Differences: New Directions and Perspectives
  • Language: en
  • Pages: 201

From Sex Differences in Neuroscience to a Neuroscience of Sex Differences: New Directions and Perspectives

This research topic aims to integrate scattered findings on sex differences in neuroscience into a broader theory of how the human brain is shaped by sex and sex hormones in order to cause the great variety of sex differences that are commonly observed. It can be assumed that these differences didn’t occur arbitrarily, but that they rather determined and still determine evolutionary success of individuals and were shaped by the processes of natural and in particular sexual selection. Therefore, sex differences are not negligible and sex difference research cannot be discriminating against one sex or the other. In fact a better understanding of the underlying causes of sex differences has g...

Programming HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation
  • Language: en
  • Pages: 141

Programming HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation

Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.

PAIN – Novel targets and new technologies
  • Language: en
  • Pages: 96

PAIN – Novel targets and new technologies

The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug...

Neurological and Psychiatric Disorders in Endocrine Diseases
  • Language: en
  • Pages: 99

Neurological and Psychiatric Disorders in Endocrine Diseases

Neurological and psychiatric disorders can occur in endocrine diseases either in the setting of the clinical manifestations of the same (i.e., hyper- or hyposecretion of hormones or peptides from the endocrine glands) or as events secondary to the pathogenetic mechanisms of the endocrinopathy (i.e., autommunity affecting endocrine glands and the brain). Also the medical or surgical treatment of the endocrine disease can sometimes determine the occurrence of neurological or psychiatric abnormalities. Moreover some genetic alterations can lead to syndromes affecting both the endocrine and the nervous system with a variety of possible manifestations. In the last couple of decades a number of as...

Neuroendocrine Control of Feeding Behavior
  • Language: en
  • Pages: 397

Neuroendocrine Control of Feeding Behavior

The hypothalamus plays a crucial role in the regulation of food intake and energy homeostasis. Hypothalamic neuronal circuits thus represent a privileged target for the treatment of eating disorders and metabolic diseases. The present eBook constitutes a unique collection of research articles and reviews that highlight new concepts and recent findings about the neuroendocrine control of feeding behavior.

The Enlightened Gene
  • Language: en
  • Pages: 274

The Enlightened Gene

Are humans inherently good? Where does compassion come from? Is death essential for life? The surprising confluence of Buddhist thought and cutting-edge biology.

Developing Ecological Consciousness
  • Language: en
  • Pages: 233

Developing Ecological Consciousness

Developing Ecological Consciousness is a unique environmental studies textbook. Rather than working through a list of environmental problems, it aims to help students become aware of the awe and wonder of our planet, understand some of the challenges facing it, and explore possibilities for action and change. This text is invaluable for courses in a variety of disciplines, including environmental studies, biology, sociology, and political science.

Neuro-Immune Interactions in Inflammation and Autoimmunity
  • Language: en
  • Pages: 222

Neuro-Immune Interactions in Inflammation and Autoimmunity

The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural c...

The Amygdala
  • Language: en
  • Pages: 422

The Amygdala

Among the components of the limbic system, the amygdala is a fascinating structure that is involved in the processes of liking and disliking and in the ways our emotions drive our actions and affect the strength of our memories. Combined with new conceptual breakthroughs, the very latest data obtained by leading world experts in amygdala function that are reviewed in this book have helped to understand how the amygdala contribute to these processes and also to a variety of neurological and neuropsychiatric pathologies. Of course, due to the rate of research advancement, all the chapters presented here correspond to precise questions addressed by experts using highly specific techniques. Ther...