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Concepts and Models for Drug Permeability Studies
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biolo...
Biomedical Applications of Functionalized Nanomaterials
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section...
Particulate Drying
In the process industry, understanding the unit operation of particulate drying is imperative to yield products with desired properties and characteristics and to ensure process safety, optimal energy efficiency and drying performance, as well as low environmental impact. There are many techniques and tools available, which can cause confusion. Particulate Drying: Techniques and Industry Applications provides an overview of various particulate drying techniques, their advantages and limitations, industrial applications, and simple design methods. This book: • Covers advances in particulate drying and their importance in the process industry • Highlights recent developments in conventiona...
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily ...
Bio-Nanomedicine for Cancer Therapy
The book covers the latest developments in biologically-inspired and derived nanomedicine for cancer therapy. The purpose of the book is to illustrate the significance of naturally-mimicking systems for enhancing the dose delivered to the tumor, to improve stability, and prolong the circulation time. Moreover, readers are presented with advanced materials such as adjuvants for immunostimulation in cancer vaccines. The book also provides a comprehensive overview of the current status of academic research. This is an ideal book for students, researchers, and professors working in nanotechnology, cancer, targeted drug delivery, controlled drug release, materials science, and biomaterials as well as companies developing cancer immunotherapy.
Advances in Physicochemical Properties of Biopolymers (Part 2)
There is considerable diversity in polymers extracted from natural sources and much work has been done to classify them according to their physical and chemical properties. In the second part of this book set, readers will find general information about the physicochemical properties of several naturally occurring polysaccharides followed by a section dedicated to their application in different fields of research and medicine. Key topics in this part include: • chitosan (properties modifications and applications) • microbial biopolymers • biopolymers present in Brazilian seeds • protein-plastic foams • biopolymer microencapsulation in the food industry • biomedical gels • collagen biomaterials • biopolymer electrospinning This reference is intended for students of applied chemistry and biochemistry who require information about the properties and applications of polysaccharides (such as chitosan) and other protein-based biopolymers.
Mucosal Delivery of Biopharmaceuticals
Biopharmaceutical medicines, the newest class of therapeutics, are quite heterogeneous and include a range of molecules such as proteins, peptides, vaccines and nucleic acids, with use in virtually all therapeutic fields (e.g. cancer and infectious diseases, vaccination, metabolic dysfunctions) and diagnostics. This edited book gives a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals, the technological strategies that have been followed so far regarding the optimization of mucosal potentialities as well as the challenges that arise with the advent of new biopharmaceutical drugs and alternative me...
Nanomedicine
This volume in the Methods in Enzymology series comprehensively covers Cancer, Cardiovascular and the central nervous system of Nanomedicine. With an international board of authors, this volume is split into sections that cover subjects such as Diabetes and nanotechnology as potential therapy, Nanomedicines for inflammatory diseases, and Development and use of ceramide nanoliposomes in cancer. - Comprehensively covers cancer and the cardiovascular and central nervous systems of nanomedicine - An international board of authors - Split into sections that cover subjects such as diabetes and nanotechnology as potential therapy, nanomedicines for inflammatory diseases, and the development and use of ceramide nanoliposomes in cancer
Cutting-Edge Applications of Nanomaterials in Biomedical Sciences
Cutting-Edge Applications of Nanomaterials in Biomedical Sciences is a comprehensive exploration of the revolutionary impact of nanotechnology on the field of medicine. This book delves into the remarkable potential of nanomaterials in advancing medical diagnostics and therapeutics, particularly in drug delivery. It serves as an indispensable guide, presenting the latest developments in nanomedicine, precision medicine, and nanoengineering while addressing the challenges and opportunities that arise. The book covers a wide range of topics, from nanomaterials for cancer therapy to their applications in imaging and diagnostics. It discusses the transformative role of nanomaterials in targeted ...
Fundamentals of Drug Delivery
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the deve...
