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Recent Advances in the Understanding of Hepatocellular Carcinogenesis, 2nd edition
Hepatocellular carcinoma (HCC) is the most common cancer of the liver and the third most cause of cancer-related deaths worldwide. The 5-year survival of HCC is less than 20%, making HCC the second most lethal malignancy; the first being pancreatic cancer. HCC usually occurs in patients with chronic liver disease in association with a variety of risk factors, including chronic liver infection with hepatitis B virus or hepatitis C virus; excessive consumption of alcohol; overeating, obesity, and nonalcoholic fatty liver disease; other metabolic liver diseases including Wilson’s disease, hemochromatosis, and alpha-1-antitrypsin deficiency; and environmental toxins such as aflatoxins. Tobacco...
