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Technical and Biological Components of Marrow Transplantation
Technical and Biological Components of Marrow Transplantation presents up to date information on the scientific and technological advances that will extend and improve the clinical application of bone marrow transplantation. The book includes the latest information on chronic myeloid leukemia and thalassemia; advances in supportive care: cytokines and progenitor expansion; and cord stem cell technology. Soon more of patients will receive marrow transplants as part of the therapy for solid tumors and metabolic disease than for the treatment of hematologic disease. The contributors to this volume describe some of these applications, hinting at yet further, exciting possibilities.
Advances and Controversies in Thalassemia Therapy
Examines the clinical features of thalassemia and current supportive and curative therapeutic strategies. Critically evaluates conventional therapies, followed by an up-to-date account of bone marrow transplantation, which is the only known cure for thalassemia. Contributors to this volume, who represent virtually all transplant centers involved in thalassemia, offer a wealth of case studies illustrating effective bone marrow transplantation. They also provide clinical guidelines for determining which patients are best suited for transplantation and discuss problems such as cyclosporine in children; patterns of graft rejection; infections; and change in growth and endocrine function.
Biological Responses in Cancer
The series of volumes entitled Biological Responses in Cancer: Progress toward Potential Applications provides information on approaches through which the interaction between neoplastic and normal cells may be modified. Each annual volume contains contributions in areas where significant prog ress has been made. Topics to be dealt with include immunologic and host defense systems, control mechanisms of cell and population growth, cell differentiation, and cell transformation. The regulatory mechanisms controlling the interactions between normal and tumor cells may be immunologic in nature or they may relate to diverse biological characteristics of tumor and normal cells and their response to...
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Myelodysplastic Syndromes & Secondary Acute Myelogenous Leukemia
Myelodysplastic syndromes are to the bone marrow what pneumonia is to the lungs; the response of an organ to a variety of etiologic insults like aging, toxic exposure, infections and auto-immunity. Among infectious causes alone, pneumonia could be the result of a variety of possible pathogens including bacterial, viral, tuberculous or fungal agents. Similarly, MDS cannot be treated as a single disease. Attempts to harness the inherent complexity of MDS by devising `classifications' which group the various syndromes as one disease is as misguided as saying that a pneumonia is not infectious because it did not respond to antibiotics. Progress in the field will occur faster when we re-analyze t...
