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Topics include: Clinical Predictors of Outcome in MPNs; Molecular pathogenesis of MPNs; Disordered signaling in MPNs; Role of TET2/ASXL1 in MPN Pathogenesis; Pathogenesis and treatment of systemic mastocytosis; Role of additional novel therapies in MPNs; Role of novel mutations in MPN pathogenesis and outcome; Role of JAK inhibitors in MPN treatment; Animal Models of MPNs; and Role of Germline Genetic Factors in MPN Pathogenesis.
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
Reprint of the original, first published in 1865.
To become a Cisco Certified Network Associate (CCNA), you must learn the hundreds of IOS commands used by Cisco routers and switches. This handy reference from Cisco networking authority Todd Lammle is just what you need to master those commands. From a thorough introduction to Cisco's basic operating system to making the transition to IPv6, Todd Lammle walks you through hundreds of commands with short, to-the-point explanations and plenty of figures and real-world examples.
Every year, there are several hundred thousand episodes of neonates and children experiencing thromboembolic incidents. These episodes of blood clotting have many causes, some congenital but most caused by underlying problems, such as arterial disease, renal disorders, systemic lupus erythematosis or leukemia. Many more are caused by therapeutic interventions in critical care. The author is a world recognized expert on the topic who has studied thousands of cases. Based on this clinical research, the author provides guidelines for the proper diagnosis and therapeutic interventions for thrombolic disorders, no matter what the cause. She covers the newest drug therapies including oral anticoagulation preparations.
Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
John Harmon returns to England after years in exile to claim his inheritance: a great fortune and a beautiful young woman to whom he is betrothed, but has never met. When Harmon’s body is pulled out of the Thames, all of London is fascinated by the mystery of the murdered man and his unclaimed riches. Socialclimbers, lawyers, teachers, a money-lender, men and women both honest and villainous will all become embroiled in this tale of love and obsession, death and rebirth.
Reserve your copy now This two volume book is an outstanding reference source on allaspects of allergy and allergic diseases. Covering virtually everyallergic condition, from the immunological and molecular basis ofthe allergic response to future trends in allergic diseaseprevention, this new international editorial team (A.B.Kay, JeanBousquet, Pat Holt and Allen Kaplan) have completely revised andupdated the text, from both a scientific and clinical perspective.References will continue to be added to the text until it goes topress making this the most up-to-date book available in thefield. This second edition consists of more than 1,800 pages containedwithin 98 chapters. The price includes a fully searchable companion CD ROM with thecomplete text and over 300 images from the book in full colour.
Osteoporosis in men is an important clinical problem that has received little attention, both in the medical arena and from the general public. Although the condition affects a higher percentage of women, it is estimated that two million men in the U.S. have osteoporosis, and three million more are at risk. The lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated.Osteoporosis in Men is the first book to explore this issue in depth. This groundbreaking text brings together eminent investigators and clinicians who interpret developments in this emerging field, and describe state-of-the-art research as well as practical ap...