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Integrins in Health and Disease
Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of in...
Computer Analysis of Images and Patterns
This volume presents the proceedings of the 11th International Conference on Computer Analysis of Images and Patterns (CAIP 2005). This conference - ries started about 20 years ago in Berlin. Initially, the conference served as a forum for meetings between scientists from Western and Eastern-block co- tries. Nowadays, the conference attracts participants from all over the world. The conference gives equal weight to posters and oral presentations, and the selected presentation mode is based on the most appropriate communication medium. The program follows a single-track format, rather than parallel s- sions. Non-overlapping oral and poster sessions ensure that all attendees have the opportuni...
Visual Affect Recognition
It is generally known that human faces, as well as body motions and gestures, provide a wealth of information about a person, such as age, race, sex and emotional state. This monograph primarily studies the perception of facial expression of emotion, and secondarily of motion and gestures, with the purpose of developing a fully automated visual affect recognition system for use in modes of human/computer interaction. The book begins with a survey of the literature on emotion perception, followed by a decription of empirical studies conducted with human participants and the construction of a face image database . On the basis of this work, a visual affect recognition system was developed, consisting of two modules: a face detection subsystem and a facia expression recognition subsystem. Details of this system are demonstrated and analyzed, and extensive performance evaluations and test results are provided. Finally, current research avenues leading to visual affect recognition via analysis of body motin and gestures are also discussed."
Handbook of Crisis Intervention and Developmental Disabilities
The Handbook of Crisis Intervention and Developmental Disabilities synthesizes a substantive range of evidence-based research on clinical treatments as well as organizational processes and policy. This comprehensive resource examines the concept of behavioral crisis in children and adults with special needs and provides a data-rich trove of research-into-practice findings. Emphasizing continuum-of-care options and evidence-based best practices, the volume examines crisis interventions across diverse treatment settings, including public and private schools, nonacademic residential settings as well as outpatient and home-based programs. Key coverage includes: Assessment of problem behaviors. C...
Lagrangian and Hamiltonian Methods for Nonlinear Control 2003
This is the second of a series of IFAC Workshops initiated in 2000. The first one chaired and organized by Profs. N. Leonard and R. Ortega, was held in Princeton in March 2000. This proceedings volume looks at the role-played by Lagrangian and Hamiltonian methods in disciplines such as classical mechanics, quantum mechanics, fluid dynamics, electrodynamics, celestial mechanics and how such methods can be practically applied in the control community. *Presents and illustrates new approaches to nonlinear control that exploit the Lagrangian and Hamiltonian structure of the system to be controlled *Highlights the important role of Lagrangian and Hamiltonian Structures as design methods
Targeting the DNA Damage Response for Cancer Therapy
This book discusses the latest developments in Poly (ADP-ribose) polymerase (PARP) inhibitor drug development. It focuses on the translational and clinical development of the latest drugs, as well as the evidence for regulatory approval of PARP inhibitors in multiple different molecular subtypes and tumor indications. The most-up-to-date information on basic scientific research on DNA repair pathways and the DNA Damage Response (DDR) is also covered. Every chapter contains insight into the preclinical, translational along with clinical aspects of a specific DDR inhibitor with key and expert opinion points reinforcing the most important concepts detailed to enable the reader to develop a deep understanding of the topic. Targeting the DNA Damage Response for Cancer Therapy comprehensively reviews the application of PARP and other DDR inhibitors across oncology disciplines. Therefore, it is a valuable resource for all medical professionals and researchers who use or who are researching the use of these inhibitors on a day-to-day basis.
Tetraspanins
Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection. The book summarises recent advances in the fields of biology in which the role of tetraspanins have been established and also covers the molecular evolution of the tetraspanin superfamily and structural aspects of the organisation of tetraspanin microdomains.
