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Sudden arrhythmic death: from basic science to clinical practice
With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far f...
Principles of Molecular Medicine
Within the framework of clinical internal medicine, they will gain critical knowledge of the many powerful molecular biology-based developments now so rapidly enhancing our understanding of the pathophysiology of disease, improving the feasibility and accuracy of diagnostic testing, and opening novel therapeutic avenues, including gene therapy. Readers will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more.
Contemporary Concepts in Cardiology
In the era of instant global communication, medicine is an international discipline characterized by a wide range of patient referral systems, world-wide discussion of clinical and research findings, and an explosion in the medical literature. Perhaps no field has progressed more than cardiology in the past few years. Contemporary Concepts in Cardiology has been conceived as a supplement to the classic cardiology textbooks for the use of practicing physicians, cardiologists-in-training, medical students, and research investigators. This volume focuses on associations between refinements in the understanding of disease and clinical applications. The material is presented in a way that limns t...
Vanished - The Truth About The Disappearance Of Madeline Mccann
'Vanished' uncovers the truth about the disappearance of Madeleine McCann.
Advances in Brain Inspired Cognitive Systems
This book constitutes the refereed proceedings of the 5th International Conference on Brain Inspired Cognitive Systems, BICS 2012, held in Shenyang, Liaoning, China in July 2012. The 46 high-quality papers presented were carefully reviewed and selected from 116 submissions. The papers are organized in topical sections on biologically inspired systems, cognitive neuroscience, models of consciousness, and neural computation.
Of Bens, Glens and Rambling Auld Men
This starts with the early post WWII years when Robert and Gordon, as young men, were first attracted to the outdoors. They hiked and climbed in the mountains of the Scottish Highlands and often slept in caves, barns, bothies and tents in both summer and winter. They made friends and climbed with many of the emerging group of mainly working class rock climbers who were pioneering ascents of the cliffs and gullies in Glencoe and Ben Nevis at that time. Their week-end adventures had them ranging across the wild moors, glens and mountains in all seasons and in all weathers. As the years passed, their lives changed. One became a youth hostel warden in N.W. Scotland, later becoming a gamekeeper and ghillie on an estate in Assynt. The other went overseas as a teacher, first to Algeria then to Saudi Arabia and finally Brunei S.E. Asia, where he stayed for nearly thirty years. The two men lost touch with each other for over forty years. At that point they met again and, while re-calling their youthful ramblings and catching up on one another’s later adventures, came to realise the uniqueness of their lives. From these two kinds of rambling comes this fascinating book.
Cardiac Drug Safety: A Bench To Bedside Approach
Ensuring the safety of new medical products remains a major challenge for the pharmaceutical industry. Cardiac safety, particularly drug-induced heart rhythm abnormalities, remains an important cause of pipeline attrition and has resulted in countless major product recalls or label changes. The risk of encountering this major adverse event continues to shape the drug development and regulatory landscape.Extensive research over the past decade has shed light on the root causes of arrhythmias that are triggered by medications and has helped drive, and optimize, drug safety testing. However, current cardiac safety platforms have several limitations and there remains a pressing unmet need to imp...
Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine
Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.
Crime, Justice and the Media
Crime, Justice and the Media examines and analyzes the relationship between the media and crime, criminals and the criminal justice system. It considers how crime and criminals have been portrayed by the media over time, applying different theoretical perspectives on the media to the way crime, criminals and justice is reported. It focuses on a number of specific areas of crime and criminal justice in terms of media representation - these areas include moral panics over specific crimes and criminals (including youth crime, cybercrime and paedophilia), the media portrayal of victims of crime and criminals and the way the media represent criminal justice agencies. The book offers a clear, accessible and comprehensive analysis of theoretical thinking on the relationship between the media, crime and criminal justice and a detailed examination of how crime, criminals and others involved in the criminal justice process are portrayed by the media. A key strength of the book is its interactive approach - throughout the text students are encouraged to respond to the material presented and think for themselves.
The Black Halo
Although best-known as one of Scotland's greatest modern poets, Iain Crichton Smith was also prolific as a writer of short stories. These pieces form a central part of his oeuvre, demonstrating the full range and versatility of his literary talent. From humour to tragedy, from inner monologues to extrovert surrealism, the diversity of his writing indicates the extraordinary range of his own reading and mental world. Crichton Smith wrote short stories throughout his life. Some are fragments, others almost novellas, and the best of them all show him to be an author of unique sensitivity and intelligence. These two collections, comprising the complete English stories, include over 45 stories never before published in book form, as well as others that have been out of print for many years, thus making it possible to judge Crichton Smith's achievement as a writer in full. Incorporates stories from The Hermit, Murdo, Mr Trill in Hades and Selected Stories.
