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Precision Cancer Therapies, Volume 1
A Thorough Compilation of the Many Scientific Breakthroughs in the Ongoing Development of Precision Cancer Therapies Related to Lymphoma Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice focuses on lymphoma, an area which has seen a remarkable number of breakthroughs in the ongoing development of precision cancer therapies. Each section on a specific biology or class of drugs has an introductory chapter written by an authority in the field, exclusively focused on the science and its relevance to cancer biology. This approach addresses the need for scientists, physicians, and the private sector to understand the broader context of the extrao...
Current List of Medical Literature
Includes section, "Recent book acquisitions" (varies: Recent United States publications) formerly published separately by the U.S. Army Medical Library.
Therapeutic Targeting of RAS Mutant Cancers
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
Sedation - E-Book
Combining essential theory with "how-to technical instruction, this concise guide is the leading reference for basic techniques in sedation and anxiety control in the dental office. The latest guidelines from the ADA and the American Society of Anesthesiologists keep you up-to-date with the latest medical standards. Content on patient management for pediatric, geriatric, physically compromised, and medically compromised patients helps you successfully treat any patient population. - In-depth discussions of the pharmacology of commonly used sedative agents allow you to fully understand properties and characteristics of drugs used. - Combines all aspects of sedation with essential theory and i...
The Theatre
Vol. for 1888 includes dramatic directory for Feb.-Dec.; vol. for 1889 includes dramatic directory for Jan.-May.
Portuguese Missionary Grammars in Asia, Africa and Brazil, 1550-1800
From the 16th century onwards, Europeans encountered languages in the Americas, Africa, and Asia which were radically different from any of the languages of the Old World. Missionaries were in the forefront of this encounter: in order to speak to potential converts, they needed to learn local languages. A great wealth of missionary grammars survives from the 16th century onwards. Some of these are precious records of the languages they document, and all of them witness their authors' attempts to develop the methods of grammatical description with which they were familiar, to accommodate dramatically new linguistic features.This book is the first monograph covering the whole Portuguese gramma...
Cutting Edge Preclinical Models in Translational Medicine
In vitro, in vivo, and in silico preclinical models hold a widely acknowledged potential, yet complex limitations. For this reason, which has been known for a long time by experimenters and modelers, the translation of “science products” to the clinic is still far. Therefore, there is a raising awareness of the need to bridge this gap by developing integrated and innovative models. Organ and tissue bioengineering is an ideal approach to foster innovative strategies in significant research and clinical areas. Similarly, in translational neuroscience research, this challenge has been taken up by intriguing fish models. However, much research based on novel methodologies has still to be performed to get the bench closer to the bedside.
