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Bacterial Activation of Type I Interferons
The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway. Bacterial Activation of Type I Interferons reviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered.
Interleukin-10
Interleukin-10 (IL-10) is regarded as an immune suppressant cytokine. This reputation is due to the experimental observation that IL-10 decreases the function of antigen presenting cells and T helper 1 type immune responses. Surprisingly, however, IL-10 has potent anti-cancer effects since most experimental models demonstrate immune-mediated anti-t
New-generation vaccines and novel vaccinal strategies against infectious diseases of livestock, wild and companion animals
Emerging and re-emerging infections, in particular those caused by viruses, are expected to rise in correlation, among other factors, with climate changes. Antibiotic resistance is another issue that will limit the therapeutic arsenal against bacterial and parasitic infections. Therefore, one must be adequately prepared to overcome and prevent current and novel infections, and vaccination remains the optimal way to fight infectious diseases in humans. This is also true for many impacting diseases of livestock and companion animals, to which there are no available vaccines. First (attenuated and inactivated) and second (subunit) generation vaccines have their limitations. To overcome this, ef...
Media Ethics
Media Ethics: Cases and Moral Reasoning challenges readers to think analytically about ethical situations in mass communication through original case studies and commentaries about real-life media experiences. This text provides a comprehensive introduction to the theoretical principles of ethical philosophies, facilitating ethical awareness. It introduces the Potter Box, with its four dimensions of moral analysis, to provide a framework for exploring the steps in moral reasoning and analyzing the cases. Focusing on a wide spectrum of ethical issues faced by media practitioners, the cases in this Eleventh Edition include the most recent issues in journalism, broadcasting, advertising, public relations and entertainment. Cases touch on issues and places worldwide, from Al Jazeera to the Xinhua News Agency, from Nigerian "brown envelopes" to PR professional standards in South Africa. Racially divisive language comes up in different communication contexts, as does celebrity influence on culture. A core textbook for classes in media ethics, communication ethics, and ethics in journalism, public relations, and advertising.
Mathematical Reviews
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