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Antiplatelet Agents
Antiplatelet therapy is the cornerstone of treatment of ischemic cardiovascular disease and over the last few years spectacular advancements in this field have been recorded. This is the first comprehensive handbook entirely dedicated to all the aspects of antiplatelet therapy. The book is divided into three main sections, pathophysiology, pharmacology and therapy, for a total of 23 chapters. A large group of leading experts from different European countries and from the USA, both from academia and industry, have contributed to the book. Besides a detailed overview on the pharmacology and clinical applications of all the currently used or of the novel antiplatelet agents, innovative approaches (e.g. intracellular signalling as an antiplatelet target, small RNAs as platelet therapeutics, etc.) or unconventional aspects (e.g. pharmacologic modulation of the inflammatory action of platelets are also treated. The book is oriented to both basic investigators and to clinicians involved with research on platelet inhibition or with the clinical use of antiplatelet therapies.
Radioimmunoassay in Basic and Clinical Pharmacology
Thirty years have elapsed since the first description by S. A. BERSON and R. S. Y ALOW of the basic principles of radioimmunoassay (RIA). During this period of time, RIA methodology has been instrumental to the growth of many areas of biomedical research, including endocrinology, oncology, hematology, and pharmacology. It has done so by providing a relatively simple universal tool allowing, for the first time, the detection of endogenous mediators that are present 12 10 in body fluids at concentrations as low as 10- _10- M. The fundamental nature of this discovery and the wide-ranging fall-out of basic and clinical knowledge derived from its application have been acknowledged by the many hon...
Platelet-dependent Vascular Occlusion
Experts in the field of platelet-dependent vascular occlusion present their papers in this volume. The topics considered are relevant to researchers in both academia and the pharmaceutical industry who are interested in vascular occlusion, as well as to clinicians in haematology and cardiology. Advances in the cellular and molecular biology of platelets and endothelial cells, biochemical and molecular mechanisms of vascular proliferation and coagulation, and novel therapeutic approaches to thrombosis and atherosclerosis are considered.
Renal Eicosanoids
Based on a symposium held June, 1987 in Capri, Italy, this volume represents reviews of the current state of knowledge in the field, covering such areas as cell biology, metabolites, pathophysiology, biosynthesis, and pharmacology. Annotation copyright Book News, Inc. Portland, Or.
Platelets in Thrombotic and Non-Thrombotic Disorders
This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
Predisposing Conditions for Acute Ischemic Syndromes
"Predisposing conditions for acute ischemic syndromes" contains the proceedings of a conference held in Garmisch-Partenkirchcn, West Germany, October 14 and 15, 1988. The editors of this volume arc most grateful to the authors for their effort to provide manuscripts before the meeting, to the sponsor, Bayer AG, for their gen erous support, and to the publishers for the efficient collaboration, all of which have made the appearance of this book possible. All authors contributed their manu scripts in advance and they arc combined with an edited version orlhe discussions to allow rapid publication. In coronary heart disease the prognosis for patients is largely determined by the occurrence of i...
