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Antimicrobial Resistance in Developing Countries
Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to ...
Low-dose antibiotics: current status and outlook for the future
Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact of the application of antibiotics for uses other than the treatment of patients and the association with such utilization with emerging drug resistance. This Research Topic “Low- dose antibiotics: current status and outlook for the future” in Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy details various aspects of the wide ranging effects of antimicrobial therapy from areas such as the regulation of host responses to modulation of bacterial virulence factors to acquisition of antibiotic resistance genes.
Becoming Good Ancestors
A brilliant writer and gifted "big picture" thinker, David Ehrenfeld is one of America's leading conservation biologists. Becoming Good Ancestors unites in a single, up-to-date framework pieces written over two decades, spanning politics, ecology, and culture, and illuminating the forces in modern society that thwart our efforts to solve today's hard questions about society and the environment. The book focuses on our present-day retreat from reality, our alienation from nature, our unthinking acceptance of new technology and rejection of the old, the loss of our ability to discriminate between events we can control and those we cannot, the denial of non-economic values, and the decline of l...
Strict and Facultative Anaerobes
Strict and Facultative Anaerobes: Medical and Environmental Aspects reviews all aspects of anaerobic bacteria, highlighting their environmental and medical importance. The first three chapters focus on taxonomy, anaerobic metabolism and the genetic regulation of anaerobic processes in strict and facultative anaerobes. The next section includes an examination of the physiological traits of anaerobic bacteria that enable them to be beneficial in one situation but hazardous to human and animal health in others. Other topics include the anaerobic nature of infections, latency, anaerobic biofilms, and toxin production. The final section reviews iron, selenate, and arsenate reduction, as well as oxidation of halogenated organics, ammonium oxidation, and acetogenesis. This important book provides detailed coverage of the wide-ranging capabilities of anaerobic bacteria. It examines their basic biology and chemistry, medical importance, and applications in biotechnology and environmental science. It is an essential reference for everyone interested in anaerobic bacteria, environmental biology, medical microbiology, and industrial bacteriology.
Thomas Jefferson
In this definitive short biography, Bernstein deftly synthesizes the massive scholarship on his subject into an insightful, evenhanded account illuminating Jefferson's central place in the American Enlightenment. Book jacket.
Mechanisms of antibiotic resistance
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse....
The multiple roles of antibiotics and antibiotic resistance in nature
Antibiotics and antibiotic resistance have most commonly been viewed in the context of human use and effects. However, both have co-existed in nature for millennia. Recently the roles of antibiotics and antibiotic resistance genes have started to be discussed in terms of functions other than bacterial inhibition and protection. This special topic will focus on both the traditional role of antibiotics as warfare mechanisms and their alternative roles and uses within nature such as antibiotics as signals or communication mechanisms, antibiotic selection at low concentrations, the non-specific role of resistance mechanisms in nature: e.g. efflux pumps, evolution of antibiotic resistance and the role of persisters in natural antibiotic resistance.
Bacterial Pathogenesis
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. - Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease - Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow - Covers safety aspects, detection, identification and speciation - Includes techniques for the study of host interactions and reactions in animals and plants - Describes biochemical and molecular genetic approaches - Essential methods for gene expression and analysis - Covers strategies and problems for disease control
Antibiotics and Antibiotic Resistance in the Environment
The presence of antibiotics, antibiotic resistance genes, and antibiotic resistant bacteria in the environment is a cause of growing worldwide concern, as it reveals the extensive impact of antibiotic abuse and other human-related pressures upon microbes. The field of detecting and measuring resistance in the environment has rapidly evolved to a systematic search of organisms and genes. This book will review the available evidence and hypotheses on where antibiotic resistance is coming from and for how long it has been there. Further, it will discuss involved maintenance pressures, resistance spread, traits and laboratory and in-silico strategies to further investigate antibiotic resistance.
The Sex Imperative
"The sex imperative - the irresistible impulse to engage in sexual relations - has enabled animals to share their genes and evolve. Maxwell traces the progress of sex from the simple sharing of genes between cells to the elaborate courtship rituals that developed so sperm could merge with egg. In the effort to join sperm and egg, species have developed some astounding and unusual sexual adaptations. As Maxwell vividly describes the sex lives of various creatures, he attests to the resiliency and amazing adaptability of life to its everchanging environment. By focusing on the diversity of animal sexual relationships, Maxwell enables us to question the very basis of sexuality: What is sex? Why...
