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The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration.
Handbook of Research on Urban and Humanitarian Logistics
City logistics is one of the most popular fields of transportation sciences, dealing with sustainably supplying cities and at the same time reducing congestion and pollution related to goods transport in urban areas. Recently, humanitarian, emergency, and crises logistics has been a subject of increasing interest, often seen from an international viewpoint. However, some of the recent natural crises have shown the importance of resilience and reliability of the current urban logistics systems. The Handbook of Research on Urban and Humanitarian Logistics is a critical scholarly publication that addresses urban logistics and resilience, sustainable urban logistics, humanitarian logistics in urban areas both for crisis or long-term, and planning for resilient urban development. Featuring a broad range of topics that discuss the new and future trends in urban logistics and resilient cities, this publication is ideal for public planners; urban planners; company managers in logistics and transport; consulting agencies; regional, national, and international institutions and organizations; researchers; academicians; and students.
Celiac Disease and Non-Celiac Gluten Sensitivity
Celiac disease is a systemic autoimmune process and appears in genetically predisposed individuals, with a well-known cause, consisting in a permanent intolerance to gluten, a protein contained in the flour of wheat, rye, barley and oats. Worldwide celiac disease affects to 1% of the Caucasian and there is recent evidence that the disease is increasing in USA and Finland among other regions in the world. It is considered to be the most prevalent disease with a genetic predisposition. The clinical forms of presentation are varied. The classical form consisting of diarrhea, anemia and failure to thrive is still common in children, but in the adult patients the symptoms resemble the irritable b...
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