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A Fluid Recovery Brasileira e o Descompromisso com a Tutela Jurisdicional Efetiva
No Brasil, a tutela coletiva dos chamados direitos individuais homogêneos segue um procedimento bifásico, que envolve fases com naturezas distintas. A primeira fase é essencialmente coletiva, conduzida pelos legitimados do art. 82 do Código de Defesa do Consumidor – CDC e encerrada, em caso de condenação do réu coletivo, por uma sentença condenatória genérica, cuja função será meramente de reconhecer a ocorrência do dano e a responsabilidade do agente. A segunda é individual e pulverizada, exigindo-se, a priori, a habilitação de cada um dos lesados para liquidação da sentença (delimitação do quantum e do cui debeatur) e posterior execução. Por diversos motivos – q...
Educação e Sertão Nordestino
A presente coletânea é uma construção coletiva composta por diversos autores da Região Nordeste do Brasil. Nossa concepção foi abordar ideias atuais que possam contribuir, de alguma forma, para a reflexão e transformação da realidade de quem reside nessa região. Ressignificando temáticas, olhares, saberes, práticas para propor uma mudança pragmática.
Phosphorus-31 NMR Spectroscopy
Nuclear Magnetic Resonance is a powerful tool, especially for the identification of 1 13 hitherto unknown organic compounds. H- and C-NMR spectroscopy is known and applied by virtually every synthetically working Organic Chemist. Con- quently, the factors governing the differences in chemical shift values, based on chemical environment, bonding, temperature, solvent, pH, etc. , are well understood, and specialty methods developed for almost every conceivable structural challenge. Proton and carbon NMR spectroscopy is part of most bachelors degree courses, with advanced methods integrated into masters degree and other graduate courses. In view of this universal knowledge about proton and carb...
Direitos Sucessórios dos Cônjuges e Conviventes - 1a Ed - 2024
Esta obra aborda as controvérsias que cercam a sucessão legítima no Brasil, focando em duas questões centrais: a exclusão prévia do direito de concorrência e o status jurídico do cônjuge e do convivente como herdeiros. Propõe-se uma discussão aprofundada e fundamentada, buscando soluções que respeitem a justiça social e a regulamentação da vida conjugal. Desta forma, no tocante ao direito concorrencial, não obstante a necessidade de sua preservação, pretende-se demonstrar que é possível a sua exclusão prévia, lege lata, com o apoio na técnica de ponderação e na metodologia civil-constitucional; bem assim nas interpretações jurídicas (semântica, literal e gramati...
Redox-Active Therapeutics
This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neg...
Marijuana and the Cannabinoids
Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.
Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?
Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
Criminal Poisoning
In this revised and expanded edition, leading forensic scientist John Trestrail offers a pioneering survey of all that is known about the use of poison as a weapon in murder. Topics range from the use of poisons in history and literature to convicting the poisoner in court, and include a review of the different types of poisons, techniques for crime scene investigation, and the critical essentials of the forensic autopsy. The author updates what is currently known about poisoners in general and their victims. The Appendix has been updated to include the more commonly used poisons, as well as the use of antifreeze as a poison.
Cancer Drug Resistance
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Recommendation Systems in Software Engineering
With the growth of public and private data stores and the emergence of off-the-shelf data-mining technology, recommendation systems have emerged that specifically address the unique challenges of navigating and interpreting software engineering data. This book collects, structures and formalizes knowledge on recommendation systems in software engineering. It adopts a pragmatic approach with an explicit focus on system design, implementation, and evaluation. The book is divided into three parts: “Part I – Techniques” introduces basics for building recommenders in software engineering, including techniques for collecting and processing software engineering data, but also for presenting r...
