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Gene Genealogies, Variation and Evolution: A primer in coalescent theory
Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the...
Statistical and Evolutionary Analysis of Biological Networks
Networks provide a very useful way to describe a wide range of different data types in biology, physics and elsewhere. Apart from providing a convenient tool to visualize highly dependent data, networks allow stringent mathematical and statistical analysis. In recent years, much progress has been achieved to interpret various types of biological network data such as transcriptomic, metabolomic and protein interaction data as well as epidemiological data. Of particular interest is to understand the organization, complexity and dynamics of biological networks and how these are influenced by network evolution and functionality. This book reviews and explores statistical, mathematical and evolut...
Mathematical Congress of the Americas
This volume contains the proceedings of the First Mathematical Congress of the Americas, held from August 5-9, 2013, in Guanajuato, México. With the participation of close to 1,000 researchers from more than 40 countries, the meeting set a benchmark for mathematics in the two continents. The papers, written by some of the plenary and invited speakers, as well as winners of MCA awards, cover new developments in classic topics such as Hopf fibrations, minimal surfaces, and Markov processes, and provide recent insights on combinatorics and geometry, isospectral spherical space forms, homogenization on manifolds, and Lagrangian cobordism, as well as applications to physics and biology.
Statistics and Informatics in Molecular Cancer Research
Molecular understanding of cancer and cancer progression is at the forefront of many research programs today. High-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the structure, and function of cells, tissues, and organisms. Correctly analyzed and interpreted these data hold the promise of bringing new markers for prognostic and diagnostic use, for new treatment schemes, and of gaining new biological insight into the evolution of cancer and its molecular, pathological, and clinical consequences. Aimed at graduates and researchers, this book discusses novel advances in informatics and statistics in molecular cancer research. Through...
Statistics and Informatics in Molecular Cancer Research
A collection of chapters from carefully chosen experts covering the theory behind the complex mathematical, statistical, and bioinformatics tools needed to extract, handle, and process data and their application to real data.
Problem Solving Handbook in Computational Biology and Bioinformatics
Bioinformatics is growing by leaps and bounds; theories/algorithms/statistical techniques are constantly evolving. Nevertheless, a core body of algorithmic ideas have emerged and researchers are beginning to adopt a "problem solving" approach to bioinformatics, wherein they use solutions to well-abstracted problems as building blocks to solve larger scope problems. Problem Solving Handbook for Computational Biology and Bioinformatics is an edited volume contributed by world renowned leaders in this field. This comprehensive handbook with problem solving emphasis, covers all relevant areas of computational biology and bioinformatics. Web resources and related themes are highlighted at every opportunity in this central easy-to-read reference. Designed for advanced-level students, researchers and professors in computer science and bioengineering as a reference or secondary text, this handbook is also suitable for professionals working in this industry.
The Cambridge Companion to Genesis
Essays explaining diverse methods and reading strategies, providing a dependable guide to understanding the Book of Genesis.
Recent Advances in Differential Equations and Applications
This work gathers a selection of outstanding papers presented at the 25th Conference on Differential Equations and Applications / 15th Conference on Applied Mathematics, held in Cartagena, Spain, in June 2017. It supports further research into both ordinary and partial differential equations, numerical analysis, dynamical systems, control and optimization, trending topics in numerical linear algebra, and the applications of mathematics to industry. The book includes 14 peer-reviewed contributions and mainly addresses researchers interested in the applications of mathematics, especially in science and engineering. It will also greatly benefit PhD students in applied mathematics, engineering and physics.
Advances in Systems Biology
The International Society for Systems Biology (ISSB) is a society aimed at advancing world-wide systems biology research by providing a forum for scientific discussions and various academic services. The ISSB helps coordinate researchers to form alliances for meeting the unique needs of multidisciplinary and international systems biology research. The annual International Conference on Systems Biology (ICSB) serves as the main meeting for the society and is one of the largest academic and commercial gatherings under the broad heading of ‘Systems Biology’.
Theories of Population Variation in Genes and Genomes
This textbook provides an authoritative introduction to both classical and coalescent approaches to population genetics. Written for graduate students and advanced undergraduates by one of the world's leading authorities in the field, the book focuses on the theoretical background of population genetics, while emphasizing the close interplay between theory and empiricism. Traditional topics such as genetic and phenotypic variation, mutation, migration, and linkage are covered and advanced by contemporary coalescent theory, which describes the genealogy of genes in a population, ultimately connecting them to a single common ancestor. Effects of selection, particularly genomic effects, are dis...
