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Concepts and Models for Drug Permeability Studies
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biolo...
Gene and Cell Delivery for Intervertebral Disc Degeneration
Intervertebral disc degeneration is one of the major causes of lower back pain for which the common therapeutic interventions are not efficient. A search for alternative therapies for lower back pain and intervertebral disc degeneration includes cell-based therapies. Unfortunately, intervertebral disc degeneration is avascular and thus a hostile environment for cell survival. Furthermore, cellular characterization in intervertebral disc degeneration, and particularly in the nucleus pulposus, is controversial, mainly due to lack of specific markers and species variability. This book adds to the knowledge on cellular and molecular therapies for intervertebral disc degeneration and associated lower back pain. Key Selling Features: Describes the ontogeny and phenotype of intervertebral disc cells Reviews the role that inflammation plays in disco-genic pain Highlights the types of cells that might be used as sources for treating degenerating intervertebral discs Summarizes current alternative therapies Explores methods for cell delivery into degenerated intervertebral discs
Revista de História da Sociedade e da Cultura
A Revista de História da Sociedade e da Cultura, fundada em 2001, é uma revista de periodicidade anual, cujos artigos são sujeitos a avaliação prévia por parte de uma comissão de arbitragem externa. Publica textos de natureza histórica (desde a Antiguidade à Época Contemporânea), noticiário de atividades científicas e recensões críticas de livros. Aceita artigos de investigadores integrados e de colaboradores do Centro de História da Sociedade e da Cultura da FCT, bem como de quaisquer outros historiadores externos à instituição, estimulando especialmente a participação de todos aqueles que, de qualquer modo, mantêm colaboração ou desenvolvem atividades em rede com o ...
X!? 2010-2020 TEN YEARS OODA
OODA is a Portuguese architecture collective, now celebrating 10 years of practice. Based in Porto with experience gained internationally in notable offices, such as OMA-Rem Koolhaas and Zaha Hadid Architects, the collective aims to expand internationally, namely New York, São Paulo and Shanghai. With a wide range of work (whether idea or built, new or rehabilitation) and participation in international competitions in Africa, America, Asia, Middle East and Europe, their work includes partnerships with Kengo Kuma and the Pritzker prize winner Souto de Moura. More than presenting and dissecting the work of the practice, this book is an adventure in technical and artistic exchanges. It is divi...
Advances in Tourism, Technology and Systems
This book features a collection of high-quality research papers presented at the International Conference on Tourism, Technology and Systems (ICOTTS 2022), held at University of Chile, Santiago de Chile, Chile, from 3 to 5 November 2022. The book is divided into two volumes, and it covers the areas of technology in tourism and the tourist experience, generations and technology in tourism, digital marketing applied to tourism and travel, mobile technologies applied to sustainable tourism, information technologies in tourism, digital transformation of tourism business, e-tourism and tourism 2.0, big data and management for travel and tourism, geotagging and tourist mobility, smart destinations, robotics in tourism, and information systems and technologies.
Nanoparticles in Life Sciences and Biomedicine
The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles, such as nanoemulsions, liposomes, nanocrystals, and nanocomplexes, applied in the diagnosis, treatment, or theranostics of several pathologies and diseases. This book reviews the most recent research and development in nanotechnology and, following a multidisciplinary approach, presents new strategies for drug delivery, including aspects from chemistry, physics, biology, and imaging methodologies and exploiting several administration routes, internalization pathways, site-specific delivery...
