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This book provides an integrated perspective on the recent advances in the development of effective biological systems using molecular biological techniques for biochemical production and analysis. This book includes metabolic engineering approaches in microbial systems, anti-apoptosis engineering in animal cell systems, and cell surface engineering in microbial and mammalian cell systems. Biological Systems Engineering contains advances in new technologies in the development of effective biological systems using molecular biological techniques for the biochemical production and analysis.
Hypertension remains the leading cause of cardiovascular morbidity and mortality in spite of current medical therapies. It has been estimated that 50% of Western civilization has hypertension and approximately 20% of patients have resistant hypertension. Renal denervation (RDN) is a minimally invasive, endovascular catheter based procedure using radiofrequency ablation aimed at treating resistant hypertension. Early studies show a high degree of effectiveness in renal denervation to treat hypertension. This book examines renal pathophysiology and the rationale for renal denervation, as well as possible long term benefits and risks of this new therapy. The myriad of devices involved in the evolution of this therapy are discussed and the book concludes with analyses of the cost effectiveness and future applications.
Percutaneous left atrial appendage (LAA) closure is an emerging technology for thromboembolic prevention in patients with atrial fibrillation (AF). The first human implantation of an LAA device occurred in 2001, and since then four devices have received CE mark approval. These devices are being widely used in Europe for LAA closure in patients who are poor candidates for long-term oral anticoagulation. In the US, the WATCHMAN device (Boston Scientific) is anticipated to receive FDA approval imminently for AF patients who are warfarin-eligible. This approval is projected to significantly expand the indications for LAA closures worldwide. Thus, the volume of procedures is anticipated to escala...
The significantly updated second edition of this important work provides an up-to-date and comprehensive overview of cardiovascular magnetic resonance imaging (CMR), a rapidly evolving tool for diagnosis and intervention of cardiovascular disease. New and updated chapters focus on recent applications of CMR such as electrophysiological ablative treatment of arrhythmias, targeted molecular MRI, and T1 mapping methods. The book presents a state-of-the-art compilation of expert contributions to the field, each examining normal and pathologic anatomy of the cardiovascular system as assessed by magnetic resonance imaging. Functional techniques such as myocardial perfusion imaging and assessment o...
''Interesting with many useful ideas and references. It covers a broad range and it is a good introduction to this field.'' ---Analyst
Finding one’s way with a map is a relatively recent phenomenon. In premodern times, maps were used, if at all, mainly for planning journeys in advance, not for guiding travelers on the road. With the exception of navigational sea charts, the use of maps by travelers only became common in the modern era; indeed, in the last two hundred years, maps have become the most ubiquitous and familiar genre of modern cartography. Examining the historical relationship between travelers, navigation, and maps, Cartographies of Travel and Navigation considers the cartographic response to the new modalities of modern travel brought about by technological and institutional developments in the twentieth cen...
The reputation of William Hogarth (1697-1764) rests largely on his pictorial stories, a series of engravings that he called "modern Moral Subjects," the most famous being the Harlot's and the Rake's Progress. In this catalog, David Bindman works backward from Hogarth's reputation today--where he is seen by some as a conservative populist and by others as a political radical--and examines his impact on various artists over the past three centuries. Bindman also sets Hogarth's prints firmly in their historical context, discussing the artist's public and the different influences on his work, from Roman satire to the politics of the day. The result is an engaging and insightful portrayal not onl...
This dictionary documents alchemical symbolism from the early centuries AD to the late-twentieth century, for use by historians of literary culture, philosophy, science and the visual arts, and readers interested in alchemy and hermeticism. Each entry includes a definition of the symbol, giving the literal (physical) and figurative (spiritual) meanings, an example of the symbol used in alchemical writing, and a quotation from a literary source. There are fifty visual images of graphic woodcuts, copperplate engravings and hand-painted emblems, some reproduced here for the first time.