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Since endothelial progenitor cells (EPCs) were first described in 1997, there has been significant debate surrounding their definition and roles; but also agreement in their potential to develop as biomarkers and cytotherapies. EPCs participate in vascular repair and postnatal angiogenesis by differentiating into endothelial cells or by producing pro–angiogenic growth factors. Various subtypes of EPCs have been studied, such as CD34+VEGFR2+ blood circulating cells, cultured endothelial colony forming cells (ECFCs), and myeloid angiogenic cells (MACs). EPCs have therapeutic potential for revascularisation and vascular repair in ischemic diseases such as myocardial infarction and diabetic vascular complications. In this eBook, we compile evidence to enable their translation including strategies to enhance the number, homing ability to the injury site and function of EPCs.
This textbook uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 29 clinical cases have been carefully selected to cover key scientific concepts and some common, and other not so common, diseases. While the principal focus is on topics relating to metabolic disease, further subjects such as connective tissue disorders, neurological disorders, auto-inflammatory disorders, infective diseases, and cancer are also addressed. Each chapter provides a specific patient report that includes the natural history, pertinent clinical laboratory data, physical findings, subsequent diagnosis, and therapy. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. Graphical diagrams are provided in each chapter for ease of comprehension.
Maps are not just diagrams of the route from A to B - from the earliest times they have helped us make sense of our world, from the very local to the global. Simply organised as a progression through time, each map is not only a beautiful work of art in its own right but also tells us about our changing perception of the earth. Sometimes, of course, maps tell lies and there are examples represented here that are meant to alter or influence our understanding of the world around us. There are maps of oceans and continents charted by heroic adventurers sailing into the unknown, at sea for years in tiny ships. For every example of a beautifully embellished map that has survived there must have b...
Lists for 19 include the Mathematical Association of America, and 1955- also the Society for Industrial and Applied Mathematics.
MBC online publishes papers that describe and interpret results of original research conserning the molecular aspects of cell structure and function.
Barber shows how arguments for states’ rights from John C. Calhoun to the present offend common sense, logic, and bedrock constitutional principles. The Constitution is a charter of positive benefits, not a contract among separate sovereigns whose function is to protect people from the central government, when there are greater dangers to confront.
In September 1938, the Munich Agreement delivered the Sudetenland to Germany. Six months later, HitlerÕs troops marched unopposed into Prague and established the Protectorate of Bohemia and MoraviaÑthe first non-German territory to be occupied by Nazi Germany. Although Czechs outnumbered Germans thirty to one, Nazi leaders were determined to make the region entirely German. Chad Bryant explores the origins and implementation of these plans as part of a wider history of Nazi rule and its consequences for the region. To make the Protectorate German, half the Czech population (and all Jews) would be expelled or killed, with the other half assimilated into a German national community with the ...