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Targeted Drug Delivery : Concepts and Design
This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Alginates and Their Biomedical Applications
This book presents a comprehensive review of the latest advances in developing alginate-based biomaterials and derivatives as well as their biomedical and pharmaceutical applications. It covers the physiochemical properties of alginates, production and formulation methods, derivatizations and characterization methods, the fundamental work on optimizing alginate polymers for defined biomedical purposes as well as the scope and effectiveness of their applications in medicine and therapeutic approaches. The book brings together new concepts and advances in harnessing alginate-based biomaterials in combination with applied technological advances to tailor their applications to medical needs. The contributions by leading academics, clinicians and researchers not only cover the fundamentals, but also open new avenues for meeting future challenges in research and clinical applications.
Targeted Therapy for the Central Nervous System
Targeted Therapy for the Central Nervous System: Formulation, Clinical Challenges, and Regulatory Strategies presents research on various delivery methods of drugs to the central nervous system and brain. This volume examines targeted therapies for neurodegenerative disorders and succinctly outlines the future of drug delivery systems, highlighting significant advancements specifically relating to central nervous system delivery. This book will be of great interest to researchers working in the field of neuroscience and pharmacology as well as clinicians (pharmacists, radiologists, psychiatrists). - Provides a current, thorough means on how drugs are delivered to the neurological system - Figures a connection amongst the physiology of drug delivery pertaining to the central nervous system, fundamentals of drug delivery, and distribution principles - Gives an accounting of clinical trials and regulatory approaches for the formulations targeting brain
Drug Discovery and Development
This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.
Nanotoxicity
Nanotoxicity: Prevention, and Antibacterial Applications of Nanomaterials focuses on the fundamental concepts for cytotoxicity and genotoxicity of nanomaterials. It sheds more light on the underlying phenomena and fundamental mechanisms through which nanomaterials interact with organisms and physiological media. The book provides good guidance for toxic prevention methods and management in the manufacture/application/disposal. The book also discusses the potential applications of nanomaterials-based antibiotics. The potential toxic effects of nanomaterials result not only from the type of base materials, but also from their size/ ligands/surface chemical modifications. This book discusses wh...
Emerging Social Issues on Targeted Drug Delivery
The world of targeted drug delivery (TDD) represents an incredible leap forward in how we treat and manage diseases . It’s a frontier where science converges with hope, precision, and, in many ways, a reimagining of healthcare itself. As we move closer to realizing a future where therapies can target specific cells or tis-sues with minimal side effects, the excitement is tempered by a growing recogni-tion of the technical, ethical, and societal challenges that come with this revolu-tionary shift in medical practice. In this drawing from the insights of re-searchers and thinkers who are deeply engaged in navigating this transformative field. Together, the following chapters, illustrate how the evolving landscape of TDD holds both immense promise and significant complexity.
Nanophytomedicine
Nanophytomedicine is a branch of medicine that involves the application of nanomedicine-based systems to phytotherapy and phytopharmacology and the use of phytonanoparticles for biomedical applications. Nanophytomedicine covers recent advances in experimental and theoretical studies on various properties of nanoparticles derived from plant sources. This book assesses the recent advancements and applications of plant-based nanoparticles and also highlights emerging concepts of biomimetics. The book contains 24 chapters encompassing various therapeutic applications of phytochemicals derived from plants, ferns, seaweeds, and so on, mediated through nanotechnology and its allied approaches. A fervent attempt has been made to compile every significant advancement in the field of phytonanomedicine so as to accelerate its momentum in the pharmaceutical sector.
Smart Micro- and Nanomaterials for Pharmaceutical Applications
Smart drug delivery refers to a targeted drug delivery or precision drug delivery system that allows drugs to be administered to a specific location in the body or at a specific time with enhanced precision and control. This approach has several advantages, including maximizing the therapeutic effects of a drug while minimizing side effects. This book presents various stimuli-responsive micro- and nanomaterials for pharmaceutical industries. This volume: Covers the global market perspective of micro- and nano-smart materials in pharmaceutical industries. Details various processing routes. Discusses mechanisms for target release. Addresses applications in oral drug delivery, anticancer agents, anti-tumor drug delivery, and drugs for management of infection. This reference work is written to support researchers in the fields of materials engineering and biotechnology with the goal of improving the diagnosis and treatment of disease and patient quality of life.
Nanomaterials
This book highlights recent advances and evolution of various nanomaterials and their potential in diverse research fields. The book covers the synthesis and characterization of various nanomaterials, followed by discussion on desired applications such as clean and green renewable energy, coating, sensors, thermal applications, microelectronics, biomedical applications such as drug carriers, nutrition, biosensors and detection of cancer cells. The chapters in this book not only illustrate the capability of nanomaterials in such novel usages but also reveal their potential drawbacks and the possible ways to overcome the pitfalls. The book covers interdisciplinary research advancement of nanomaterials, beneficial for researchers and professionals working in both science and engineering.
Novel Phytopharmaceutical for Management of Disorders
Novel Phytopharmaceutical for Management of Disorders covers recent advances surrounding phytopharmaceuticals and their potential uses in the management of several disorders as well as in cosmetic benefits. Sections cover the concepts of phytopharmaceuticals and current highlights in disease management. This book also emphasizes phytopharmaceutical drug delivery studies in vivo–in vitro study to various target organs like lungs, liver, and brain. This book provides key information for everyone interested in disease management, drug discovery, and delivery, including medicinal chemists, cosmetic experts, nutritionists, toxicologists, drug formulators, and health care professionals. Students...
