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Diagnostic Molecular Biology, Second Edition describes the fundamentals of molecular biology in a clear, concise manner with each technique explained within its conceptual framework and current applications of clinical laboratory techniques comprehensively covered. This targeted approach covers the principles of molecular biology, including basic knowledge of nucleic acids, proteins and chromosomes; the basic techniques and instrumentations commonly used in the field of molecular biology, including detailed procedures and explanations; and the applications of the principles and techniques currently employed in the clinical laboratory. Topics such as whole exome sequencing, whole genome seque...
"True wellness innovation requires the recruitment of multi-disciplinary participants. This book breaks the mold with examples from healthcare experts and other professionals who have leveraged informatics to better the lives of their constituents." — Jason Helgerson, Founder & CEO, Helgerson Solutions Group LLC Developed for those training in academic centers as well as for those already "out in the field," this book looks at how attorneys, behavioral health experts, business development experts, chief information officers, chief medical officers, chief nursing information officers, consumer advocates, cryptographic experts, futurists, geneticists, informaticists, managed care executives, nurses, pharmacists, physicians, public health professionals, software developers, systems security officers, and workforce experts are collaborating on a "team-based," IT-enabled approach to improve healthcare.
The book provides a comprehensive review of apoptotic cell death. It discusses the mechanism of apoptosis and emerging principles of drug resistance in cancer. The development of novel drug targets and drug delivery systems for inhibiting or inducing apoptosis are the ultimate goal. Further, upregulation of anti-apoptotic proteins and loss of pro-apoptotic proteins strongly favors apoptosis evasion. The ability of cancer cells to evade apoptosis is critical for the progression and clonal expansion of malignantly transformed cells. Defective apoptosis imparts proliferative advantage to cancer cells or cells with the potential to become cancerous. The mechanisms employed by cancer cells to evade apoptosis can be used in the strategic design of therapeutic regimens aimed at exploiting apoptotic signaling networks to ensure tumor-specific cell death. This book presents knowledge of the molecular mechanisms of defective apoptosis that could be translated into the development of novel therapeutic agents and therapeutic modalities for cancer treatment.
A powerful element in twentieth-century Chinese politics has been the myth of Chinese resistance to Japan's seizure of Manchuria in 1931. Investigating the shifting alliances of key players in that event, Rana Mitter traces the development of the narrative of resistance to the occupation and shows how it became part of China's political consciousness, enduring even today. After Japan's September 1931 military strike leading to a takeover of the Northeast, the Chinese responded in three major ways: collaboration, resistance in exile, and resistance on the ground. What motives prompted some Chinese to collaborate, others to resist? What were conditions like under the Japanese? Through careful reading of Chinese and Japanese sources, particularly local government records, newspapers, and journals published both inside and outside occupied Manchuria, Mitter sheds important new light on these questions.
The enigmatic personal qualities that marked Sun Yat-sen during his lifetime have encouraged controversy concerning him ever since his death more than a generation ago. Mr. Schiffrin's book deals with the first forty years of Sun's life, and attempts to find the key to this controversial personality. His study is at once biography and history, for it goes beyond Sun to the whole texture of Chinese history of Sun's time. Drawing on diplomatic archives, police reports, personal interviews, contemporary newspapers, and other hitherto unused sources in Chinese, Japanese, and Western languages, the author reveals unsuspected facets of Sun's versatile plotting on three continents, and traces the convolutions of his pragmatic style in unprecedented detail.
Hui-neng, the patriarchal ancestor of all existing Ch'an/Zen, was invented by Shen-hui (684-758) based on a fusion of Buddhist and Confucian themes. This propaganda led to the creation of a large hagiographical literature that determined the trajectory of Ch'an.
Supplements 1-14 have Authors sections only; supplements 15- include an additional section: Parasite-subject catalogue.