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Since a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conception) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deters many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subse...
Written in clear and simple language, 'Design for a Life' offers an understanding of the science that lies behind many current controversies in parenting, education, social policy and medicine.
Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.
There are far-reaching consequences of the way our body has evolved to fight disease. This book describes how genes link our struggle with disease to compatibility with others, the wiring of our brain, and success in pregnancy.
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在高樓大廈林立之間的中環至半山自動扶手電梯系統,其原來的設計雖被視作便利該地區的市民出入,以紓緩區內日見嚴重的交通擠塞的輔助性「交通工具」,卻因設計別具特色,扶手電梯沿途所經過的一帶遍佈歷史建築,成為香港島其中一道迷人的風景線。 本書匯聚多位大學學者和歷史專家編纂的11篇文章,以中上環半山電梯為中軸,記錄了早期半山電梯沿途一帶的大街小巷與各式建築物、傳奇人物的足跡故事,以及他們對社區以至整個社會、宗教、文化發展帶來的影響,重塑香港早期的政治、經濟發展與香港民生狀況等社會歷史的面貌。本書亦為不同時期的香港發展補充了相當重要的歷史資料,透視了香港自開埠以來的國際商貿及文化的影響力,窺探小城如何由小漁村發展成華洋薈萃、多元包容和自由開放的國際大都會。
Successful implantation and early development need a union of healthy genes and an optimal uterine environment. The 48th RCOG Study Group, an international multidisciplinary expert forum, considered factors involved in preparation for implantation within the uterus; how to determine a good egg and good sperm; lessons from animal models; transgenic and genomic technologies; sporadic and recurrent early pregnancy loss; single-embryo transfer; and the developmental consequences of assisted reproduction technologies. This book presents the findings of the Study Group, with sections covering: • preparation for implantation - the uterine environment • the embryo • lessons from animal models (transgenics) and novel technologies • clinical sequelae.