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Pain
This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.
Molecular and Functional Models in Neuropsychiatry
The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.
Anthony Cerami
Since the turn of the new millennium, ‘translational research’, the scientific process of bringing disease-targeted knowledge from the laboratory to treat patients in the clinic, has gone mainstream and is now practiced by large universities and institutes across the globe. Into this dynamic of the rapidly changing world of translational medical research this book sets the life of one of the discipline’s most influential practitioners, Anthony Cerami. His work spans more than five decades and culminated in the discovery, invention and development of diagnostics and therapeutics used daily by millions of people. Students in molecular medicine and investigators pursuing basic science in ...
The Misfit Economy
A book that argues that lessons in creativity, innovation, salesmanship, and entrepreneurship can come from surprising places: pirates, bootleggers, counterfeiters, hustlers, and others living and working on the margins of business and society.
Deriving Drug Discovery Value from Large-Scale Genetic Bioresources
The process of discovering and developing a new drug or therapy is extremely costly and time consuming, and recently, it has been estimated that the creation of a new medicine costs on average more than $2 billion and takes 10 years to reach patients. The challenges associated with bringing new medicines to market have led many pharmaceutical companies to seek out innovative methods for streamlining their drug discovery research. One way to increase the odds of success for compounds in the drug development pipeline is to adopt genetically guided strategies for drug discovery, and recognizing the potential benefits of collecting genetic and phenotypic information across specific populations, ...
We Do Things Differently
Our systems are failing. Old models - for education, healthcare and government, food production, energy supply - are creaking under the weight of modern challenges. As the world's population heads towards 10 billion, it's clear we need new approaches. Futurologist Mark Stevenson sets out to find them, across four continents. From Brazilian favelas to high tech Boston, from rural India to a shed inventor in England's home counties, We Do Things Differently travels the world to find the advance guard re-imagining our future. At each stop, he meets innovators who have already succeeded in challenging the status quo, pioneering new ways to make our world more sustainable, equitable and humane. Populated by extraordinary characters, We Do Things Differently paints an enthralling picture of what can be done to address the world's most pressing dilemmas, offering a much needed dose of down-to-earth optimism. It is a window on (and a roadmap to) a different and better future.
ACUPUNCTURE IN MEDICINE
An exponential growth to medicine and therapeutic procedure has been possible only in modern science. The sciences in general are a post-Renaissance development. The disciplines developed in its methods have superseded those of previous traditions. Therapeutic traditions progressed in human biology, their practices helping to cure or alleviate some of the ailments perceived in the lore of human constitution. Whatever its interpretation, bio-physiology has a substantial species continuity enabling a social use for Traditional Therapies. A rationale for them within medicine and its science must be established. Investigating Chinese Acupuncture may suggest an approach to the scientific potential of other Traditional Therapeutics and, importantly, address the issue of public safety. Knowledge transmitted through European, Asian, Arab and Persian civilisations includes medical traditions that contributed to the Renaissance development of Medical Sciences. Acupuncture today is indeed a constructive metaphor for transacting and developing specific traditional therapeutic methods in Health Systems of nations, while acknowledging limitations and improving safe delivery.
Light to those in Darkness
Now widely recognised within palliative care, the concept of ‘total pain’ is an intensely theological one at heart. In Light to those in Darkness clinician and theologian Dr Charlie Bell holds up the concept to theological scrutiny. Bell reflects on the ways that the doctrine of ‘the communion of saints’, might be used to help the church understand how it can address “total pain” within individuals, and collective trauma within the wider community. As such the book offers both an important theological reflection for those in pastoral care roles and a broader challenge to the church to become a place of solidarity and accompaniment.
Bioproperty, Biomedicine and Deliberative Governance
Biomedical patents have been the subject of heated debate. Regulatory agencies such as the European Patent Office make small decisions with big implications, which escape scrutiny and revision, when they decide who has access to expensive diagnostic tests, whether human embryonic stem cells can be traded in markets, and under what circumstances human health is more important than animal welfare. Moreover, the administration of the Trade Related Aspects of Intellectual Property Rights by the World Trade Organization has raised considerable disquiet as it has arguably created grave health inequities. Those doubting the merits of the one size fits all approach ask whether priority should be giv...
Big Data, Little Data, No Data
An examination of the uses of data within a changing knowledge infrastructure, offering analysis and case studies from the sciences, social sciences, and humanities. “Big Data” is on the covers of Science, Nature, the Economist, and Wired magazines, on the front pages of the Wall Street Journal and the New York Times. But despite the media hyperbole, as Christine Borgman points out in this examination of data and scholarly research, having the right data is usually better than having more data; little data can be just as valuable as big data. In many cases, there are no data—because relevant data don't exist, cannot be found, or are not available. Moreover, data sharing is difficult, i...
