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Alcohol, Tobacco and Cancer
Excessive alcohol consumption and smoking are among the major risk factors for cancer. Simultaneous indulgence further increases the risk for especially cancer of the upper aerodigestive tract due to the interaction of several metabolic and genetic factors. The first part of this book addresses in detail the correlations between alcohol and carcinogenicity, focusing on specific organs such as the upper aerodigestive tract, liver, colon, pancreas and breast. This includes the impairment of methionine-folate metabolism and DNA methylation by alcohol, as well as the use of s-adenosylmethionine to prevent cancer. Furthermore, the synergistic effects of reactive oxygen species and iron in produci...
The Eicosanoids
This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).
Resistance in Hematologic Malignancies and Cancer
Resistance in Hematologic Malignancies and Cancer brings together the molecular, cellular, and biochemical basis/principles of various mechanisms of resistance to treatment in hematologic malignancies. Even though main mechanisms of resistance are the same in different types of tumours there are specific signalling pathways involved in resistance in hematological malignancies and of course specific treatments In 11 chapters, Resistance in Hematologic Malignancies and Cancer describes the development of treatment resistance in hematological malignancies, the role of MiRNA in resistance, the role of the immune system in resistance prediction, as well as the latest knowledge from clinical resea...
Therapy Resistance in Prostate Cancer
Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies. Therapy Resistance in Prostate Cancer: Mechanisms and Insights highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and new therapies that can be proposed to overcome this resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world to delve deeper into the pat...
Certainly Will Die
Six months after jailing mobsters, Andy Miller starts a new life unsuccessfully avoiding investigating crime. When Christiaan Johannson asks her to help recover stolen emeralds in Madrid, she's hesitant to forgive the months of radio silence. Christiaan still resists divulging his secret past life. When he is tasked to investigate a kidnapping in Scotland, Andy insists on coming—whether he likes it or not. British gambler Peter Spencer has the hots for Andy, but she still yearns for an unavailable Christiaan. The three travel Europe avoiding vengeful villains and searching for clues before time runs out for the captive girl. Three is a crowd, and two men is one too many for Andy…and Christiaan. Someone has to go. Who will she choose?
Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer
Strategies for Overcoming Chemotherapy Resistance in Cervical Cancer: From Molecular Insights to Precision Solutions, Volume 21 highlights different strategies to reverse chemotherapy resistance in cervical cancer. The book puts a strong focus on strategies to reverse chemotherapy resistance as well as strategies for early detection of the resistance, enhancing precision oncology in terms of patient care and maximizing patient management. The book also looks at virally induced resistance to chemotherapy and recommends combination therapies that can maximize the reversal of this resistance.In 10 chapters, the book not only gives an overview of cervical cancer and chemotherapy as treatment, bu...
A Need-to-Know Basis: Secrets of Your Favorite Foods and Stimulants
This purely academic reference text was inspired by the somewhat dated "PDR for Herbal Medicines." There are plenty of natural medicine guides out there that target people who frequently shop at health food or specialty food markets, but this one is different. The majority of people in this world find their food at markets that carry staple food items, and so I have created a book that allows the average individual to understand far more about the foods and stimulants that they already enjoy. This guide is divided up into sections -- one for liver health, relative to detoxification, obesity, and diabetes; one regarding the foods that fight & foods that exacerbate cancers; one for the rather awesome and odd effects of herbs and spices; and one for foods which interact with or are Monoamine Oxidase Inhibitors (a common class of drugs prescribed for depression). These particulars focus on the most prevalent diseases of the Western world which, with study and application, you just may avoid.
Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies
Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer.
Neuroendocrinology of Gastrointestinal Ulceration
Proceedings of a meeting held in Esterel, Quebec, Canada, September 13-15, 1989.
