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The basic principles of the phenomenon "erection" have been known since the pioneering work of Kolliker, Eckhard and Langley in the nineteenth century. Nonetheless, under the influence of Freud, erectile dysfunction was predominantly at tributed to psychogenic factors. A more liberal perception of sexuality since the 1960s, the development of new and refined diagnostic techniques, and the expansion of basic research activity resulted in a new concept of erectile dysfunction, identifying arteriogenic, venogenic, endocrinologic or myopathic (cavernous smooth muscle dysfunction) factors. From this research other considerations such as autonomic innervation, cavernous endo thelial intactness or ...
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Although impotence may be the most widely recognized manifestation of male sexual dysfunction, many other forms of sexual disorders do not involve the erectile mechanism, from deficiencies of desire to disturbances in ejaculatory function to the failure of detumescence. With such a myriad-and often co-existing-number of disorders, the successful tr
A major new international reference work on andrology from the EAU Section of Andrological Urology covering such issues as male infertility, erectile dysfunction, late-onset hypogonadism, and reproductive cancers that engages with contemporary concern for evidence based practice, minimizing interventions, and promoting male reproductive heal
This book fulfils the need for a general urology text primarily urologists in training. It has a novel format by having a clinical chapter always preceded by a scientific foundation chapter. The scientific chapter is geared toward answering questions for boards and understanding pathophysiology, is concise and relevant. The clinical chapter is written around evidence-based medicine and in "how-to" format with algorithms, with reference to AUA & EAU guidelines, well illustrated.
The diagnosis and treatment of Benign Prostate Hyperplasia (BPH) is considered to be one of the most important topics in urology and afflicts millions of older men world-wide. This pocketbook will cover the entire background, diagnostic process and treatment options available to patients suffering from lower urinary tract sumptoms due to BPH.
With Americans paying more than $200 billion each year for prescription pills, the pharmaceutical business is the most profitable in the nation. The popularity of prescription drugs in recent decades has remade the doctor/patient relationship, instituting prescription-writing and pill-taking as an integral part of medical practice and everyday life. Medicating Modern America examines the meanings behind this pharmaceutical revolution through the interconnected histories of eight of the most influential and important drugs: antibiotics, mood stabilizers, hormone replacement therapy, oral contraceptives, tranquilizers, stimulants, statins, and Viagra. All of these drugs have been popular, prof...
This book fulfils the need for a general urology text primarily urologists in training. It has a novel format by having a clinical chapter always preceded by a scientific foundation chapter. The scientific chapter is geared toward answering questions for boards and understanding pathophysiology, is concise and relevant. The clinical chapter is written around evidence-based medicine and in "how-to" format with algorithms, with reference to AUA & EAU guidelines, well illustrated.
A comprehensive guide to the therapeutic benefits of light and color and how they affect our physical and psychological well-being • Shares scientific research on how different wavelengths of light influence our cells, brain function, sleep patterns, and emotional stability • Examines several forms of light therapy, including chromotherapy, heliotherapy, actinotherapy, and thermotherapy • Explains how to use light and color therapy, maximize the benefits of sunlight, and avoid the health risks of new light sources such as compact fluorescents and LEDs Beginning with sun worship in prehistory and sunshine therapies in ancient Egypt, Greece, and India, light has long been associated with...