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Chemist and Druggist
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Grappling with the Multifaceted World of the DNA Damage Response
DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.
Our Wyant Family
Peter Wyant (1782-1855) and his wife Rebecca are the pioneer Wyants of Catawba and Lincoln Counties, North Carolina. Includes descendants in North Carolina through 1986.
Daniel Warlick of Lincoln County and His Descendants
Johann Daniel Warlick emigrated from Germany to Pennsylvania in 1729. He married Maria Margaretta Marstellar in about 1736. They had three children. He married Maria Barbara Schindler in about 1746 and had seven more children. They moved to Lincoln County, North Carolina in 1749. Descendants and relatives lived in Pennsylvania, North Carolina, Alabama, Tennessee and elsewhere.
