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Molecular Machines Involved in Peroxisome Biogenesis and Maintenance
In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.
Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation
Eukaryotic cells contain distinct membrane-bound organelles, which compartmentalise cellular proteins to fulfil a variety of vital functions. Many organelles have long been regarded as isolated and static entities (e.g., peroxisomes, mitochondria, lipid droplets), but it is now evident that they display dynamic changes, interact with each other, share certain proteins and show metabolic cooperation and cross-talk. Despite great advances in the identification and characterisation of essential components and molecular mechanisms associated with the biogenesis and function of organelles, information on how organelles interact and are incorporated into metabolic pathways and signaling networks i...
Contracting Human Rights
By chronicling the continuing contest over the reach, range, and regime of rights, Contracting Human Rights analyzes the way forward in an era of many challenges. This multidisciplinary book contributes to building understanding of the maturation of human rights, from a dissident doctrine to a dynamic parameter of global governance and civil society. Through an examination of both global and local challenges to human rights, including loopholes, backlash, accountability, and new opportunities to move forward, this book analyzes trends across multiple-issue areas.
8th Workshop on Theory, Phenomenology and Experiments in Flavour Physics
This book is a collection of invited contributions presented at the 8th edition of the International Workshop on Theory, Phenomenology and Experiments in Flavour Physics, held on the Island of Capri, Italy, on 11–13 June 2022. It is a joint workshop between experimentalists and theoreticians aiming at debating recent results and hot topics in flavour physics, in an interdisciplinary effort. Flavour, electroweak physics and neutrino physics are all foremost in the assessment of results within the standard model and search for physics beyond. Anomalies in flavour physics are hints on new physics, while with neutrino masses and oscillations the new physics has already started. Contributions deal mainly with the flavour anomalies, the flavour problem from leptons to quarks and back, including continuous versus discrete symmetries, and the connections between the Higgs sector and neutrinos, embracing see-saw models and Higgs potential analyses. Focus is on neutrinos, at high and low scales, including LHC searches and CLVF, leptogenesis, connections with dark sectors and NP mediators, non-standard neutrino interactions and the problem of the nature of massive neutrinos.
Kirche der Zukunft – Zukunft der Kirche
Mit der Leidenschaft des Aufbruchs Wie denken junge Pfarrerinnen und Pfarrer über die Zukunft der Kirche? Was fürchten sie? Wovon träumen sie? Welche Ideen und sogar Visionen haben die, die die Zukunft von Kirche und Gemeinde wesentlich mitgestalten und begleiten werden. In diesem Buch melden sich 23 Pfarrerinnen und Pfarrer zu Wort, die spannende und auch radikale Ideen entwickeln, wie sich in der Kirche etwas ändern kann. Ein überraschend anderes Buch voller Gedanken, Träume und Ideen, ohne Angst vor Provokation und mit der Leidenschaft des Aufbruchs.
Authentizität
Authentizitat ist ein in unserem kulturellen Raum allgegenwartiges Phanomen. Doch wem oder was begegnen wir, wenn wir meinen, uns selbst verwirklichen oder alternativ einfach uns selbst treu sein zu mussen? Christoph Wiesinger zeigt, dass wir auf ein Selbst geworfen werden, das zwar als homogener Nukleus der Person projiziert werden kann, sich aber bei genauerem Hinsehen als komplexe sozial verinnerlichte Struktur entpuppt. Das Selbst ist keineswegs objektiv zu fassen, sondern unterliegt sozialen Genesen und wird durch soziale Adressierung unterschiedlich formiert. Das Ereignis von Authentizitat gibt somit Anlass zur Reflexion der Differenz zwischen Erwartung und Erfahrung. Christoph Wiesinger legt die Strukturen des Phanomens der Authentizitat frei, zeigt die theologischen Implikationen auf und diskutiert die praktisch-theologischen Konsequenzen.
Urteilen lernen
Biographische Informationen Prof. Dr. Ingrid Schoberth hat den Lehrstuhl für Praktische Theologie/Religionspädagogik an der Universität Heidelberg inne. Christoph Wiesinger ist Assistent am Lehrstuhl für Praktische Theologie/Religionspädagogik an der Universität Heidelberg.
