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The Mononuclear Phagocyte System in Infectious Disease
The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel and tailor of the immune system. As sentinels, MPS cells are found in blood and within tissues throughout the body to patrol against pathogenic insult. The strate...
Global Burden and Challenges of Melioidosis
This book is the definitive reference regarding the global status of melioidosis in 2018. Melioidosis is one of the most neglected tropical diseases (NTDs), so much so that it is not even included in the WHO list of NTDs. Yet modeling suggests that it kills more people worldwide every year than diseases that are much better known, such as leptospirosis and dengue. The reasons for this under-recognition are numerous, including the fact that it mainly affects the disadvantaged rural poor in areas that are poorly supplied with the diagnostic capability to make the diagnosis. In 22 separate articles, expert authors from around the world have summarized what is known about the burden of the disea...
Buruli Ulcer
A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.
Spanish Books in the Europe of the Enlightenment (Paris and London)
In Spanish Books in the Europe of the Enlightenment (Paris and London) Nicolás Bas recreates, using a bibliographical approach, the manner in which Spain was regarded in Europe in the eighteenth century, by consulting booksellers’ catalogues, private book collections and key auctions in Paris and London.
Phenotypic Drug Discovery
Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of novel medical entities. This book aims to equip researchers with a thought-provoking guide to the application and development of contemporary phenotypic drug discovery for clinical success.
Routledge Handbook of Drugs and Sport
Doping has become one of the most important and high-profile issues in contemporary sport. Shocking cases such as that of Lance Armstrong and the US Postal cycling team have exposed the complicated relationships between athletes, teams, physicians, sports governing bodies, drugs providers, and judicial systems, all locked in a constant struggle for competitive advantage. The Routledge Handbook of Drugs and Sport is simply the most comprehensive and authoritative survey of social scientific research on this hugely important issue ever to be published. It presents an overview of key topics, problems, ideas, concepts and cases across seven thematic sections, which include chapters addressing: T...
