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Invertebrate Historecognition
Historecognition, broadly defined, spans the processes responsible for the regulation of the genetic integrity of self in the face of conspecific (allogeneic) and heterospecific (xenogeneic) nonself. The existence of precise historecognition systems in the invertebrates can be traced back to Bancroft's discovery in 1903 of ,strain specific regulation of colony fusion in the compound ascidian Botryllus schlosseri, and Wilson's report in 1907 of species-specific sponge re-aggregation. Despite this provocative history, invertebrate historecognition remained largely unexplored for over half a century, while studies of vertebrate immune systems prospered. Then, in the 1970's, interest in inverteb...
Contemporary Topics in Immunochemistry
In 1897, Ehrlich suggested that natural preformed receptors from the surface of cells provided immunity to various chemical substances. Many years later, in 1940, Pauling proffered the concept that antibodies comprised a single poly peptide chain and that each end of the protein could form an antigen-binding site. Burnet tried to explain the diversity of antibody specificity by hypothesizing that it was cell-derived. These hypotheses probably have led to as much or more experimentation and discussion than any other of the many conjectures set forth to explain immunity on a molecular and cellular basis. Extensive investigations, initially stimulated by these propositions, proved Pauling's not...
Cancer and IgE
Erika Jensen-Jarolim and Manuel L. Penichet 1. 1 Background Infectious diseases, being the major burden in the history of mankind worldwide th until the beginning of the 20 century, were important triggers in the understanding of immunological mechanisms. In contrast to infectious diseases, reports of all- gies and cancers were less common, but increased tremendously within the last century. Based on the US mortality data of the National Center for Health Statistics, Centers for Disease Control and Prevention 2009, a recent report from the American Cancer Society indicated that the number of cancer deaths increased approximately from 100,000 to 550,000 per year between 1930 and 2006, paralle...
Archaeology, History, and Predictive Modeling
Fort Polk Military Reservation encompasses approximately 139,000 acres in western Louisiana 40 miles southwest of Alexandria. As a result of federal mandates for cultural resource investigation, more archaeological work has been undertaken there, beginning in the 1970s, than has occurred at any other comparably sized area in Louisiana or at most other localities in the southeastern United States. The extensive program of survey, excavation, testing, and large-scale data and artifact recovery, as well as historic and archival research, has yielded a massive amount of information. While superbly curated by the U.S. Army, the material has been difficult to examine and comprehend in its totality...
Heal
How man’s best friend could help cure man’s greatest scourge: “An Emperor of All Maladies for dog lovers” (Dr. Sarah Boston, author of Lucky Dog: How Being a Veterinarian Saved My Life). Drawn from extensive research, on-the-ground reporting, and personal experience, this book explores the fascinating role dogs (and cats) are playing in the search of cures for cancer. Learn how veterinarians and oncologists are working together to discover new treatments—cutting-edge therapies designed to help both animals and people suffering from cancer. Heal introduces readers to the field of comparative oncology by describing several research projects aimed at finding new therapies for cancers ...
Heparanase
Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to...
Innovation in Vaccinology
Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology plat...
