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A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folat...
Amazing medical breakthroughs are made every day. In the past decades, medical researchers have cured diseases that were once deadly and devised new methods to heal that were once unimaginable. This title follows the development of antibiotics, including premodern forerunners to antibiotics, groundbreaking discoveries and the doctors who made them, and where the science is heading in the future. Learn how antibiotics work and why scientists need to continually discover new drugs. Sidebars, full-color photos, a glossary, and well-placed graphs, charts, and maps, enhance this engaging title. Aligned to Common Core Standards and correlated to state standards. Essential Library is an imprint of Abdo Publishing, a division of ABDO.
A provocative look at how cowardice has been understood from ancient times to the present Coward. It's a grave insult, likely to provoke anger, shame, even violence. But what exactly is cowardice? When terrorists are called cowards, does it mean the same as when the term is applied to soldiers? And what, if anything, does cowardice have to do with the rest of us? Bringing together sources from court-martial cases to literary and film classics such as Dante's Inferno, The Red Badge of Courage, and The Thin Red Line, Cowardice recounts the great harm that both cowards and the fear of seeming cowardly have done, and traces the idea of cowardice’s power to its evolutionary roots. But Chris Wal...
Based on a world-class curriculum and cutting-edge industry practices, Stop Motion Filmmaking offers step-by-step instruction in everything from puppet making and studio set-up to animation and filmmaking. Reflecting exciting advancements in the medium, animator and educator Christopher Walsh focuses closely on digital filmmaking techniques, and offers specific instruction for creating 3D designed and printed puppet components as well as hand-crafted elements. The book is enriched by exclusive online content in the form of detailed tutorials and examples, and by dynamic sidebars and inserts. Further accented by interviews with leading professionals from both the independent and major studio worlds, Stop Motion Filmmaking is designed for dedicated students of the art form, and provides invaluable training for any serious artist who is driven to bring frame-by-frame worlds to life through puppet animation.
Covering the major classes of posttranslational modifications, Posttranslational Modification of Proteins is the first comprehensive treatment of this burgeoning area of proteome diversification.
This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
'Shocking, scathing, entertaining.' Guardian 'Incredibly compelling.' The Times 'Heart-breaking.' Sunday Times Where can a tin of tuna buy you clean clothes? Where is it easier to get 'spice' than paracetamol? Where does self-harm barely raise an eyebrow? Welcome to Her Majesty's Prison Service. Like most people, documentary-maker Chris Atkins didn't spend much time thinking about prisons. But after becoming embroiled in a dodgy scheme to fund his latest film, he was sent down for five years. His new home would be HMP Wandsworth, one of the largest and most dysfunctional prisons in Europe. With a cast of characters ranging from wily drug dealers to senior officials bent on endless reform, this powerful memoir uncovers the horrifying reality behind the locked gates. Filled with dark humour and shocking stories, A Bit of a Stretch reveals why our creaking prison system is sorely costing us all - and why you should care.
In Gramsci's Political Thought, Carlos Nelson Coutinho offers an analysis of the evolution of the political thought of Antonio Gramsci. Focusing on central concepts of the Prison Notebooks and relating them to the history of modern political ideas, the book also demonstrates that Gramsci’s ideas continue to be relevant resources for understanding the controversies of our present time. Written by a leading Brazilian Marxist theorist, Gramsci's Political Thought provides one of the most succinct and theoretically focused introductions to the thought of Antonio Gramsci available internationally.
“With wry humor and profound sensitivity, Walsh takes what is mundane and transforms it into something otherworldly with sentences that can make your heart stop. A feat of language.” —Kirkus Reviews, starred review “Joanna Walsh's haunting and unforgettable stories enact a literal vertigo—the feeling that if I fall I will fall not toward the earth but into space—by probing the spaces between things. Waiting for news in a children's hospital, pondering her husband's multiple online flirtations or observing the tourists and locals at a third-world archeological site, her narrator approaches the suppressed state of panic coursing beneath things that are normally tamed by our blunted perceptions of ordinary life. Vertigo is an original and breathtaking book.” (Chris Kraus)