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Union list catalog of the lithographic views of cities and towns made during the 19th century.
Bath is the home of America's oldest county fair. The commmunity was planned as western New York's "Queen City," a great metropolis, with broad tree-lined boulevards and spacious squares. Airplanes and ladders were made here, and four railroads-from the "champagne train" to the "kick and push" line-ran through town. Today, Bath remains a town of wide avenues, well-kept greens, dramatic cliffs, busy dairies, and the famous fair that has been held every year for nearly two centuries. Bath serves as the welcoming, wide-open back door to the Finger Lakes.
This book concerns how estrogens are synthesized in the brain and their two modes of action on behavior: a slow process involving gene transcription and a faster action at the cell membrane. The significance of the regulation and distribution of the estrogen synthesizing enzyme aromatase in the brain is also highlighted.
The optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. There was, hence, an urgent need for a book covering this field in an authoritative, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to achieve optimal pharmacokinetic properties in research series. These properties include gastrointestinal absorption, protein binding, brain permeation, and metabolic profile. Toxicological issues are, of course, also of utmost importance. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.n̓.
No detailed description available for "Medicinal Implications in Cytochrome P-450 Catalyzed Biotransformations".
Proceedings of the NATO Advanced Research Workshop on Molecular Signals in Microbe-Plant Symbiotic and Pathogenic Systems, held at Biddinghuizen, The Netherlands, May 21-26, 1989