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Handbook of Traumatic Brain Injury and Neurodegeneration
Holbourne’s theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk’ syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experime...
Concussion
The increasing recognition of concussion and its associated consequences has focused international attention on mild traumatic brain injury. The need for early diagnosis, evaluation, and management has expanded dramatically. This volume includes the experience of leading experts who describe the recent advances in the pathophysiology, biomechanics, imaging definition, and management of concussion. Advanced imaging and electrophysiological techniques are being used to help delineate the underlying metabolic and ultrastructural effects of concussive injuries. Papers in this volume review the role of emerging techniques including fMRI, SPECT, PET, DTI, MRS, and MEG, as well as report on multimo...
Mitochondria in Pathogenesis
Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells. As such, they are crucial to the healthy functioning of cells. Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease, from maternally inherited genetic disorders to metabolism defects, aging, stroke, and neurodegenerative diseases such as Parkinson's, Alzheimer's, and Lou Gehrig's disease. This book brings together top researchers whose work in examining the pathophysiologic processes will lead to new strategies for prevention and treatment.
Neuropsychology
"an overview of the important developments in neuropsychology that cannot be found from the perusal of journals alone. Interest in the reviews collected in this volume will likely go beyond neuropsychology and extend to researchers exploering brain-behavior relationships, the study of disease and injury as they affect brain function, and the rehabilitation of individuals who have suffered brain injury." from back cover.
Vascular Mechanisms in CNS Trauma
While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.
Ionic Liquids UnCOILed
Ionic Liquids UnCOILed presents decisively important reviews on new processes and recent developments in ionic liquid technology with an emphasis on commercial applications in which ionic liquids are replacing, or may replace, processes currently using conventional solvents. Ranging from applied to theoretical, synthetic to analytical, and biotechnological to electrochemical, the book features eleven chapters written by an international group of key academic and industrial chemists, exercising the judicious evaluation which they are uniquely qualified to do. This book is a must for R&D chemists in industrial, governmental and academic laboratories, and for commercial developers of environmentally-friendly, sustainable processes.
Asthma and COPD
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
Higher Plant Cell Respiration
I am honored by the editor's invitation to write a Preface for this volume. As a member of an older generation of plant physiologists, my lineage in plant respiration traces back to F. F. BLACKMAN through the privilege of having M. THOMAS and W. O. JAMES, two of his "students," as my mentors. How the subject has changed in 40 years! In those dark ages B. 14C. most of the information available was hard-won from long-term experiments using the input-output approach. Respiratory changes in response to treatments were measured by laborious gas analysis or by titration of alkali from masses of Pettenkofer tubes; the Warburg respir ometer was just beginning to be used for plant studies by pioneers...
Vanilloid Receptor TRPV1 in Drug Discovery
Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it "the holy grail" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arth...
